1-苄基-4-羟基-2-氧代-1,2-二氢-1,8-萘啶-3-羧酸乙酯合成路线 (共 1 条)
反应条件
1: diethyl malonate With sodium hydride in isobutyramide T=20°C; 0.5 h; 2: N-benzyl-2H-pyridolt;2,3-dgt;lt;1.3gt;oxazine-2,4 1H-dione in isobutyramide T=110°C; 4 h; 3: With hydrogenchloride in isobutyramide; water T=0°C; pH=3;
参考文献
AVANIR PHARMACEUTICALS
Patent: WO2005/21546 A1, 2005 ;
Location in patent: Page/Page column 112; 160-161 ;