benzotriazol-1-ol; dicyclohexyl-carbodiimide in various solvent(s) T=48 - 50°C; 1.5 h; Yield given;

1: HOBT, DCC / various solvent(s) / 1.5 h / 48 - 50 °C 2: 80 percent / DBU / acetonitrile / 1 h View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: 93 percent / Cs₂CO₃ / acetonitrile; H₂O / 2.5 h / 30 - 35 &deg;C<br />2: aq. phosphate buffer, Triton X-100 / 37 &deg;C / pH 7, lipase PS-800<br /> <br /> &nbsp;