4-(三甲基甲硅烷基)苯胺合成路线 （共 11 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethanol P=760.051 Torr;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/80328 A1, 2005 ;
Location in patent: Page/Page column 12; 34 ;
WO 2005/080328 A1
反应条件
diphenyl-(o-hydroxyphenyl)-phosphine; tetrabutylammomium bromide; PdCl(π-C3H5)2 in toluene T=100°C; Substitution; Silylation; 24 h;
参考文献
Shirakawa; Kurahashi; Yoshida; Hiyama
Chemical Communications, 2000 , # 19 p. 1895 - 1896
反应条件
methoxylamine hydrochloride; n-butyllithium in tetrahydrofuran; hexane T=-78 - 60°C; 24 h; Inert atmosphereCooling with acetone-dry ice; stereospecific reaction;
参考文献
Mlynarski, Scott N.; Karns, Alexander S.; Morken, James P.
Journal of the American Chemical Society, 2012 , vol. 134, # 40 p. 16449 - 16451,3
反应条件
dicyclohexyl(2',4',6'-triisopropyl-5-methoxy-3,4,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; C50H70NO4PPdS; C50H70NO4PPdS; dicyclohexyl(2',4',6'-triisopropyl-4-methoxy-3,5,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; ammonia; sodium t-butanolate in 1,4-dioxane T=80°C; 24 h; Inert atmosphere;
参考文献
Cheung, Chi Wai; Surry, David S.; Buchwald, Stephen L.
Organic Letters, 2013 , vol. 15, # 14 p. 3734 - 3737
反应条件
hydroxylamine hydrochloride; potassium hydrogencarbonate in methanol 0.5 h; Yield given;
参考文献
Sadighi, Joseph P.; Singer, Robert A.; Buchwald, Stephen L.
Journal of the American Chemical Society, 1998 , vol. 120, # 20 p. 4960 - 4976
反应条件
1: 1.) n-BuLi / 1.) hexane, THF, -78 deg C, 30 min, 2.) hexane, THF, RT, 45 min 2: H2NOH*HCl, KHCO3 / methanol / 0.5 h View Scheme
参考文献
Sadighi, Joseph P.; Singer, Robert A.; Buchwald, Stephen L.
Journal of the American Chemical Society, 1998 , vol. 120, # 20 p. 4960 - 4976
反应条件
1: 90 percent / molecular sieves 5A / toluene / 18 h / Heating 2: 1.) n-BuLi / 1.) hexane, THF, -78 deg C, 30 min, 2.) hexane, THF, RT, 45 min 3: H2NOH*HCl, KHCO3 / methanol / 0.5 h View Scheme
参考文献
Sadighi, Joseph P.; Singer, Robert A.; Buchwald, Stephen L.
Journal of the American Chemical Society, 1998 , vol. 120, # 20 p. 4960 - 4976
反应条件
1: 65 percent / tetrakis(triphenylphosphine)palladium(0) / xylene / 3 h / 150 - 160 °C 2: ammonium formate / 10percent Pd/C / methanol / 0.5 h View Scheme
参考文献
Kimes, Alane S.; Wilson, Alan A.; Scheffel, Ursula; Campbell, Bruce G.; London, Edythe D.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 25 p. 4683 - 4689
反应条件
1: nitric acid; acetic anhydride / 1.5 h / Reflux 2: palladium 10 on activated carbon; hydrogen / toluene / 760.05 Torr View Scheme
参考文献
Lothian, Aileen P.; Ramsden, Christopher A.; Shaw, Maxine M.; Smith, Rachel G.
Tetrahedron, 2011 , vol. 67, # 15 p. 2788 - 2793
参考文献
Sakata; Hashimoto
Yakugaku Zasshi, 1959 , vol. 79, p. 872
Chem.Abstr., 1960 , p. 357
