hydrogenchloride; water T=110°C; 72 h; Sealed vessel;

hydrogenchloride; water T=110°C; 72 h; Sealed tube;

1: 82 percent / 55percent NaH / dimethylformamide / -10 deg C, 30 min, RT, 1 h 2: 74 percent / iPr2NH, 1.6M n-butyllithium / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 2 h / -78 °C 3: 6M HCl / 12 h / 110 °C / sealed View Scheme

1: 91 percent / HCl / ethyl acetate / 1 h / Ambient temperature 2: 82 percent / 55percent NaH / dimethylformamide / -10 deg C, 30 min, RT, 1 h 3: 74 percent / iPr2NH, 1.6M n-butyllithium / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 2 h / -78 °C 4: 6M HCl / 12 h / 110 °C / sealed View Scheme

1: 74 percent / iPr2NH, 1.6M n-butyllithium / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 2 h / -78 °C 2: 6M HCl / 12 h / 110 °C / sealed View Scheme

aluminium trichloride; dihydrogen peroxide Ambient temperature;

1: H2O 2: concentrated aqueous HI View Scheme