2,4,6-三氯-5-乙基嘧啶合成路线 （共 13 条）
反应条件
trichlorophosphate in N,N-dimethyl-aniline Inert atmosphere;
参考文献
Tang, Jing; Maddali, Kasthuraiah; Dreis, Christine D.; Sham, Yuk Y.; Vince, Robert; Pommier, Yves; Wang, Zhengqiang
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2400 - 2402
反应条件
1: sodium methylate / methanol / Inert atmosphere; Reflux 2: trichlorophosphate / N,N-dimethyl-aniline / Inert atmosphere View Scheme
参考文献
Saneyoshi; Watanabe
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 7 p. 2673 - 2678
反应条件
1: methanol / 0 °C 2: alcohol; zinc dust; fuming hydrochloric acid / 60 - 70 °C 3: hydrochloric acid / beim Eindampfen View Scheme
参考文献
v. Merkatz
Chemische Berichte, 1919 , vol. 52, p. 876
反应条件
1: 12 h / 0 °C 2: 43 percent / NaH / dimethylformamide / 24 h / Ambient temperature 3: 70 percent / NaH, O2 / dimethylformamide / 72 h View Scheme
参考文献
Tang, Jing; Maddali, Kasthuraiah; Dreis, Christine D.; Sham, Yuk Y.; Vince, Robert; Pommier, Yves; Wang, Zhengqiang
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2400 - 2402
反应条件
ammonia T=210°C; im Rohr;
参考文献
v. Merkatz
Chemische Berichte, 1919 , vol. 52, p. 876
参考文献
v. Merkatz
Chemische Berichte, 1919 , vol. 52, p. 876
反应条件
water; sodium hydroxide 0.5 h; Reflux;
参考文献
Al-Turkistani, Abdulghafoor A.; Al-Deeb, Omar A.; El-Brollosy, Nasser R.; El-Emam, Ali A.
Molecules, 2011 , vol. 16, # 6 p. 4764 - 4774
反应条件
1: acetonitrile / 1 h 2: potassium tert-butoxide / 3 h / 75 °C 3: Raney Ni W-2 / ethanol / 3 h / Heating View Scheme
参考文献
v. Merkatz
Chemische Berichte, 1919 , vol. 52, p. 876
反应条件
1: alcoholic ammonia / 160 °C / im Rohr
2: hydriodic acid; red phosphorus
View Scheme
参考文献
v. Merkatz
Chemische Berichte, 1919 , vol. 52, p. 876
参考文献
v. Merkatz
Chemische Berichte, 1919 , vol. 52, p. 876
