4,6-二氯-2,5-二甲基嘧啶合成路线 (共 7 条)
反应条件
trichlorophosphate 8 h; Heating / reflux;
参考文献
US2006/52398 A1, ;
Page/Page column 75 ;
参考文献
Journal of Organic Chemistry, , vol. 17, p. 1320,1322
Chemische Berichte, , vol. 71, p. 87,99
参考文献
Journal of Organic Chemistry, , vol. 17, p. 1320,1322
参考文献
SUNOVION PHARMACEUTICALS INC.; CAMPBELL, John, Emerson; HEWITT, Michael, Charles; JONES, Philip; XIE, Linghong
Patent: WO2011/150156 A2, 2011 ;
Location in patent: Page/Page column 124 ;
WO 2011/150156 A2
参考文献
Holland
Chemistry and Industry (London, United Kingdom), 1954 , p. 786
参考文献
Henze et al.
Journal of Organic Chemistry, 1952 , vol. 17, p. 1320,1322
反应条件
1: dibenzoyl peroxide; CCl4; N-bromo-succinimide
2: ethanol / anschliessenden Hydrieren an Palladium/Kohle und Behandeln mit konz.HCl
View Scheme
参考文献
Hasegawa
Pharmaceutical Bulletin, 1953 , vol. 1, p. 387,389