4,6-二氯-2-甲基嘧啶合成路线 （共 28 条）
参考文献
VIFOR (INTERNATIONAL) AG
Patent: US2012/202806 A1, 2012 ;
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethanol; water; toluene
Suzuki Coupling; 24 h; HeatingInert atmosphere;
参考文献
Achelle, Sylvain; Robin-Le Guen, Francoise
Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4491 - 4496
反应条件
1: ethanol / 0.5 h / Heating
2: 80 percent / 2M aq. NaOH
View Scheme
参考文献
Hurst, Derek T.
Australian Journal of Chemistry, 1983 , vol. 36, # 7 p. 1477 - 1482
反应条件
in methanol
T=20°C; Substitution;
参考文献
Nezu, Yukio; Miyazaki, Masahiro; Sugiyama, Kazuhiko; Kajiwara, Ikuo
Pesticide Science, 1996 , vol. 47, # 2 p. 103 - 114
反应条件
palladium on activated charcoal; diethyl ether; water
Hydrogenation;
参考文献
Smith; Christensen
Journal of Organic Chemistry, 1955 , vol. 20, p. 829,833,835
反应条件
copper; potassium carbonate
beim Erwaermen des Reaktionsprodukts mit methanol. Natriummethylat;
参考文献
Nordmark-Werke
Patent: DE926131 , 1951 ;
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran; water
T=20°C; 7 h;
参考文献
TAISHO PHARMACEUTICAL CO., LTD.; Arena Pharmaceuticals, Inc
Patent: WO2005/95357 A2, 2005 ;
Location in patent: Page/Page column 166 ;
WO 2005/095357 A2
反应条件
potassium carbonate; hydrazine in tetrahydrofuran
T=20°C; 13 h;
参考文献
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Patent: WO2007/65940 A1, 2007 ;
Location in patent: Page/Page column 43; 63 ;
