4,6-二氯-2-甲基嘧啶合成路线 （共 28 条）
反应条件
trichlorophosphate Heating;
参考文献
Farard, Julien; Loge, Cedric; Pfeiffer, Bruno; Lesur, Brigitte; Duflos, Muriel
Tetrahedron Letters, 2009 , vol. 50, # 41 p. 5729 - 5732
参考文献
Journal of Organic Chemistry, , vol. 17, p. 1320,1322
Journal of the Chemical Society, , p. 383,384
Journal of the Chemical Society, , p. 318,321
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran; water T=20°C; 9 h;
参考文献
TAISHO PHARMACEUTICAL CO., LTD.; Arena Pharmaceuticals, Inc
Patent: WO2005/95357 A2, 2005 ;
Location in patent: Page/Page column 115; 116 ;
WO 2005/095357 A2
反应条件
in ethanol T=20 - 25°C; 5 h;
参考文献
Brown; Lan; Mori
Australian Journal of Chemistry, 1984 , vol. 37, # 10 p. 2093 - 2101
反应条件
1: ammonium hydroxide / isopropyl alcohol / 18 h / 90 °C 2: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 12 h / |Reflux View Scheme
参考文献
MANNKIND CORPORATION; TOLERO PHARMACEUTICALS, INC.; ZENG, Qingping; FARIS, Mary; MOLLARD, Alexis; WARNER, Steven L.; FLYNN, Gary A.
Patent: WO2014/52365 A1, 2014 ;
反应条件
sodium hydroxide; palladium on activated charcoal; diethyl ether Hydrogenation;
参考文献
Wiley; Slaymaker
Journal of the American Chemical Society, 1957 , vol. 79, p. 2233,2234
反应条件
1: methylmagnesium bromide With zinc dibromide in tetrahydrofuran; diethyl ether T=-60°C; 1 h; 2: 2-methyl-4,6-dichloro-pyrimidine With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; diethyl ether T=60°C; 8 h;
参考文献
TAISHO PHARMACEUTICAL CO., LTD.; Arena Pharmaceuticals, Inc
Patent: WO2005/95357 A2, 2005 ;
Location in patent: Page/Page column 167; 168 ;
WO 2005/095357 A2
反应条件
bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide T=110°C; 20 h;
参考文献
Hanan, Garry S.; Schubert, Ulrich S.; Volkmer, Dirk; Riviere, Emmanuel; Lehn, Jean-Marie; Kyritsakas, Nathalie; Fischer, Jean
Canadian Journal of Chemistry, 1997 , vol. 75, # 2 p. 169 - 182
反应条件
1.1: dichloromethane / 2.5 h / 30 °C 2.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl / toluene / 16 h / Reflux 2.2: 0.17 h 2.3: 1 h / 10 - 15 °C 3.1: triethylamine; phenylphosphoric acid dichloride / dichloromethane / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Nanjing Cavendish Bio-Engineering Technology Co., Ltd.; Yan, Rong
Patent: EP2532662 A1, 2012 ;
反应条件
potassium carbonate; bis-triphenylphosphine-palladium(II) chloride in 1,4-dioxane T=60 - 80°C; 9 h;
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED; MIZUNO, Hajime
Patent: WO2010/134478 A1, 2010 ;
Location in patent: Page/Page column 187; 188 ;
