1-(4-氟苯基)-1-甲基乙胺合成路线 （共 8 条）
反应条件
1: methyllithium With cerium(III) chloride; lithium bromide in tetrahydrofuran; diethyl ether T=-78°C; 0.75 h; 2: 4-fluorobenzenecarbonitrile in tetrahydrofuran; diethyl ether T=-78°C; 0.666667 h; 3: With ammonia; water in tetrahydrofuran; diethyl ether 12 h;
参考文献
PHARMACIA and UPJOHN COMPANY LLC
Patent: WO2007/20502 A2, 2007 ;
Location in patent: Page/Page column 37 ;
WO 2007/020502 A2
反应条件
methyllithium; triethylamine; CeCl3 in tetrahydrofuran; diethyl ether; ethanol; ethyl acetate
参考文献
Merck Frosst Canada and Co.
Patent: US6200993 B1, 2001 ;
US 6200993 B1
参考文献
Sankyo Company, Limited
Patent: US5536714 A1, 1996 ;
反应条件
hydrogen; Lindlar's catalyst in ethanol
参考文献
Chemistry - A European Journal, , vol. 13, # 33 p. 9207 - 9215
反应条件
aluminium trichloride; nitrogen trichloride; 1-bromo-1,1-dimethylethane in 1,2-dichloro-ethane
参考文献
Journal of Organic Chemistry, , vol. 33, p. 4515 - 4520
反应条件
hydrogenchloride in water 70-80 deg C, 0.5 h; reflux, 0.5 h;
参考文献
Agricultural and Biological Chemistry, , vol. 49, # 12 p. 3563 - 3568
反应条件
1: 1.) SOCl2; 2.) HCl gas, 3.) ZnCl2 / 1.) pyridine 2: 8N hydrochloric acid / H2O / 70-80 deg C, 0.5 h; reflux, 0.5 h View Scheme
参考文献
Agricultural and Biological Chemistry, , vol. 49, # 12 p. 3563 - 3568
反应条件
1: tetrahydrofuran 2: 1.) SOCl2; 2.) HCl gas, 3.) ZnCl2 / 1.) pyridine 3: 8N hydrochloric acid / H2O / 70-80 deg C, 0.5 h; reflux, 0.5 h View Scheme
参考文献
Agricultural and Biological Chemistry, , vol. 49, # 12 p. 3563 - 3568
