1-Boc-氮杂环丁二烯-3-甲醛合成路线 （共 7 条）
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine in dichloromethane T=-78 - 20°C;
参考文献
WO2010/80357 A1, ;
Page/Page column 45-46 ;
WO 2010/080357 A1
反应条件
in tetrahydrofuran; ethyl acetate; toluene
反应条件
hydrogenchloride; dimethyl sulfoxide; triethylamine in n-heptane; dichloromethane; ethyl acetate
反应条件
bis[(S,S,S)-DiazaPhos-SPE]; [rhodium(I)(carbonyl)2(acetylacetonate)]; hydrogen in tetrahydrofuran; toluene T=35°C; P=8000.32 Torr; 12 h; enantioselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 132, # 40 p. 14027 - 14029
反应条件
1: NEt3 / tetrahydrofuran / 0.67 h / 0 °C 2: LiBH4 / tetrahydrofuran / 12 h / 20 °C 3: 1.11 g / oxalyl chloride; DMSO; NEt3 / CH2Cl2 / -78 - 20 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 34, # 5 p. 363 - 380
反应条件
1: 20 g / NaOH / tetrahydrofuran; H2O / 12 h / 20 °C 2: NEt3 / tetrahydrofuran / 0.67 h / 0 °C 3: LiBH4 / tetrahydrofuran / 12 h / 20 °C 4: 1.11 g / oxalyl chloride; DMSO; NEt3 / CH2Cl2 / -78 - 20 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 34, # 5 p. 363 - 380
反应条件
ammonia in water T=0 - 20°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; COGAN, Derek; MOSS, Neil; SARKO, Christopher Ronald; BAMFORD, Samantha Jayne; LOKE, Pui Leng; NAPIER, Spencer Charles, R.; TYE, Heather; WHITTAKER, Mark
Patent: WO2010/80357 A1, 2010 ;
Location in patent: Page/Page column 46 ;
WO 2010/080357 A1
