4-氨基-3-甲氧基苯甲腈(9ci)合成路线 （共 6 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethyl acetate T=20°C; P=2585.81 Torr; 0.75 h;
参考文献
Bartkovitz, David Joseph; Chu, Xin-Jie; Ding, Qingjie; Karnachi, Prabha Saba; Liu, Jin-Jun; So, Sung-Sau; Zhang, Jing; Zhang, Zhuming
Patent: US2012/46306 A1, 2012 ;
Location in patent: Page/Page column 33 ;
反应条件
1: 20 percent / 70percent HNO3; Ac2O / 1 h / 50 °C 2: 60 percent / H2 / 5percent Pt/C / ethanol / 24 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 6 p. 1187 - 1202
反应条件
1: trifluoroacetic anhydride; pyridine / 1,4-dioxane / 5 h / 20 °C 2: hydrogen / palladium 10 on activated carbon / ethyl acetate / 0.75 h / 20 °C / 2585.81 Torr View Scheme
反应条件
1: thionyl chloride / 2 h / Reflux 2: ammonia / methanol / 72 h / 20 °C 3: trifluoroacetic anhydride; pyridine / 1,4-dioxane / 5 h / 20 °C 4: hydrogen / palladium 10 on activated carbon / ethyl acetate / 0.75 h / 20 °C / 2585.81 Torr View Scheme
反应条件
in pyridine; N,N-dimethyl-formamide Reflux;
参考文献
Bakunov, Stanislav A.; Bakunova, Svetlana M.; Wenzler, Tanja; Ghebru, Maedot; Werbovetz, Karl A.; Brun, Reto; Tidwell, Richard R.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 1 p. 254 - 272
反应条件
1: ammonia / methanol / 72 h / 20 °C 2: trifluoroacetic anhydride; pyridine / 1,4-dioxane / 5 h / 20 °C 3: hydrogen / palladium 10 on activated carbon / ethyl acetate / 0.75 h / 20 °C / 2585.81 Torr View Scheme
