1-(2,4-二羟基苯基)-2-(4-羟基苯基)-乙酮合成路线 （共 22 条）
反应条件
sodium hydrogencarbonate; toluene-4-sulfonic acid in 3,4-dihydro-2H-pyran; ethyl acetate
参考文献
Kuenzer, Hermann; Jautelat, Rolf; Zorn, Ludwig; Hegele-Hartung, Christa; Kollenkirchen, Uwe; Fritzemeier, Karl-Heinrich
Patent: US2004/34017 A1, 2004 ;
反应条件
1: potassium carbonate / acetone / 30 - 35 °C 2: potassium carbonate / acetone / 1) 10-15 min, 40-50 deg C 2) 1 h, 60-70 deg C 3: 62.5 percent / 4 percent aq. sodium carbonate / ethanol / 1 h / Heating 4: 90.8 percent / 10 percent methanolic hydrochloric acid / methanol / 0.25 h / Heating View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 26, # 1-12 p. 136 - 139
反应条件
1: diethyl ether / Einleiten von Chlorwasserstoff und Erhitzen des Reaktionsprodukts mit Wasser
2: sodium acetate
View Scheme
参考文献
Deodhar, Mandar; Wood, Kasey; Black, David Stc; Kumar, Naresh
Tetrahedron Letters, 2012 , vol. 53, # 49 p. 6697 - 6700,4
Title/Abstract Full Text Show Details
Deodhar, Mandar; Wood, Kasey; Black, David Stc; Kumar, Naresh
Tetrahedron Letters, 2012 , vol. 53, # 49 p. 6697 - 6700
反应条件
1: 69 percent / TsOH / 2.5 h / 0 °C
2: 1.) piperidine, 2.) Cs2CO3, H2O / 1.) benzene, reflux, 60 h, 2.) acetone, reflux, 19 h
3: tetrahydrofuran / 3 h / -78 - 20 °C
4: aq. AcOH / 0.5 h / 90 °C
View Scheme
参考文献
Gauthier; Caron; Cloutier; Dory; Favre; Larouche; Mailhot; Ouellet; Schwerdtfeger; Leblanc; Martel; Simard; Merand; Belanger; Labrie
Journal of Medicinal Chemistry, 1997 , vol. 40, # 14 p. 2117 - 2122
反应条件
methanesulfonyl chloride in N,N-dimethyl-formamide
T=60 - 70°C; 1.5 h;
参考文献
Waehaelae, Kristiina; Hase, Tapio A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 12 p. 3005 - 3008
反应条件
4-(N,N-dimethlyamino)pyridine
T=100°C; 4 h;
参考文献
Li, Wanmei; Liu, Fangming; Zhang, Pengfei
Journal of Chemical Research, 2008 , # 12 p. 683 - 685
反应条件
1: N,N-dimethyl-formamide With phosphorus pentachloride
T=55°C; Chlorination; 0.333333 h;
2: 2,4,4'-trihydroxy deoxybenzoin With boron trifluoride diethyl etherate in N,N-dimethyl-formamide
T=20°C; Cycloaddition; 1 h;
参考文献
Balasubramanian, Sreenivasan; Nair, Muraleedharan G.
Synthetic Communications, 2000 , vol. 30, # 3 p. 469 - 484
反应条件
boron trifluoride diethyl etherate; methanesulfonyl chloride
T=100°C; 2 h;
参考文献
Mascayano, Carolina; Espinosa, Victoria; Sepulveda-Boza, Silvia; Hoobler, Eric K.; Perry, Steve
Chemical Biology and Drug Design, 2013 , vol. 82, # 3 p. 317 - 325
反应条件
boron trifluoride diethyl etherate; acetic anhydride in diethyl ether; acetic acid
Heating;
参考文献
Jah, Hem Chandra; Zilliken, Fritz; Breitmaier, Eberhard
Angewandte Chemie, 1981 , vol. 93, # 1 p. 129 - 130
反应条件
1: 2,4,4'-trihydroxy deoxybenzoin With boron trifluoride diethyl etherate in N,N-dimethyl-formamide
T=0°C;
2: methanesulfonyl chloride T=100°C; 2 h;
参考文献
Yadav, Dinesh K.; Gautam, Abnish K.; Kureel, Jyoti; Srivastava, Kamini; Sahai, Mahendra; Singh, Divya; Chattopadhyay, Naibedya; Maurya, Rakesh
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 2 p. 677 - 681
