2-甲氧基-5-(三氟甲基)苯甲酸甲酯合成路线 （共 4 条）
反应条件
copper(l) iodide in N,N-dimethyl-formamide; toluene T=140 - 160°C; 6.5 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 44, # 4 p. 734 - 745
反应条件
1: 5-amino-2-methoxybenzoic acid methyl ester With hydrogenchloride in water T=0°C; 0.0833333 h; Inert atmosphereSchlenk technique; 2: With tert.-butylnitrite T=0°C; 0.25 h; Inert atmosphereSchlenk technique; 3: trifluoromethylsilver T=-78 - 20°C; 4 h; Inert atmosphereSchlenk technique;
参考文献
Journal of the American Chemical Society, , vol. 135, # 28 p. 10330 - 10333
反应条件
boron tribromide in dichloromethane 2 h; Ambient temperature;
参考文献
Yamamoto, Satoshi; Hashiguchi, Shohei; Miki, Shokyo; Igata, Yumiko; Watanabe, Toshifumi; Shiraishi, Mitsuru
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 4 p. 734 - 745
反应条件
diisobutylaluminium hydride in dichloromethane
T=0 - 20°C;
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2004/82779 A1, 2004 ;
Location in patent: Page 91-92 ;
US 20040082779 A1
