2-甲基-4-氧-4-苯基丁酸合成路线 （共 38 条）
反应条件
sodium hydroxide; water in tetrahydrofuran 4 h;
参考文献
LG LIFE SCIENCES LTD.
Patent: WO2005/35497 A1, 2005 ;
Location in patent: Page/Page column 31 ;
WO 2005/035497 A1
参考文献
Potatov, V. M.; Dem'yanovich, V. M.; Vendrova, O. E.; Strel'tsova, E. S.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, # 11 p. 2080 - 2083
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 11 p. 2329 - 2333
反应条件
1: α-phenyl-4-morpholinoacetonitrile With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; 2: methacrylic acid methyl ester in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
Pawar; Waghmare; Lokhande
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006 , vol. 45, # 11 p. 2549 - 2551
反应条件
hydrogen; palladium on activated charcoal in acetic acid 24 h; Ambient temperature;
参考文献
Zimmer, Reinhold; Hoffmann, Matthias; Reissig, Hans-Ulrich
Chemische Berichte, 1992 , vol. 125, # 10 p. 2243 - 2248
反应条件
hydrogenchloride in ethanol; water 4.5 h; Heating;
参考文献
Kurihara, Takushi; Miki, Masuo; Santo, Kazunori; Harusawa, Shinya; Yoneda, Ryuji
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 11 p. 4620 - 4628
反应条件
1: LDA / tetrahydrofuran / -78 °C 3: H(1+) View Scheme
参考文献
Journal of the American Chemical Society, , vol. 106, # 4 p. 1146 - 1148
反应条件
1: 85 percent / p-TsOH / toluene / 8 h / Heating 2: LDA / tetrahydrofuran / -78 °C 4: H(1+) View Scheme
参考文献
Journal of the American Chemical Society, , vol. 106, # 4 p. 1146 - 1148
反应条件
aluminium trichloride T=40°C; 2 h;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 54, # 10 p. 3219 - 3220
反应条件
methanol; palladium on activated charcoal Hydrogenation;
参考文献
Journal of the Chemical Society, , p. 2139,2141
反应条件
1: aluminium chloride 2: palladium/charcoal; methanol / Hydrogenation View Scheme
参考文献
Journal of the Chemical Society, , p. 2139,2141
