1: phenylacetylene With dimethyl zinc in toluene T=0°C; 0.5 h; 2: With titanium(IV) isopropylate; (R)-2,2'-dihydroxy-1,1'-binaphthyl; phenol in tetrahydrofuran T=0°C; 0.5 h; 3: isobutyraldehyde in tetrahydrofuran; toluene T=0°C; Title compound not separated from byproducts;

[(R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine](p-cymene)ruthenium in isopropyl alcohol T=20°C; Noyori Asymmetric Hydrogenation; Inert atmosphere; enantioselective reaction;

zink diflate; Methylephedrine; triethylamine in toluene T=25°C; 2 h;

sodium sulfate; Birman's catalyst in chloroform T=0°C; 10.5 h;

dimethylsulfide borane complex; (C(C6H5)2(CH2)3NB(CH3)(O) in tetrahydrofuran T=-30°C; 1 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

[Rh((R)-BINAP)]BF4 in dichloromethane T=25°C; 28 h;

暂无反应条件数据

1: 1.) n-BuLi / 1) THF, hexane, 0 deg C, 15 min; 2) THF, hexane, 0 deg C, 30 min 2: 4 Angstroem molecular sieves, MnO2 / CCl4 / 0.33 h 3: borane methyl sulfide complex, (C(C6H5)2(CH2)3NB(CH3)(O) / tetrahydrofuran / 1 h / -30 °C View Scheme