1-(5,5,8,8-四甲基-5,6,7,8-四氢萘-2-基)乙烷-1-酮合成路线 （共 17 条）
反应条件
AlCl3, aluminium chloride
参考文献
WISCONSIN ALUMNI RESEARCH FOUNDATION
Patent: WO2007/5568 A1, 2007 ;
Location in patent: Page/Page column 10 ;
WO 2007/005568 A1
反应条件
1: acetyl chloride With AlCl3, aluminium chloride in dichloromethane T=0°C; 0.0833333 h; 2: 1,2,3,4-tetrahydro-1,1,4,4-tetramethyl naphthalene in dichloromethane T=20°C; 3 h;
参考文献
Tsang, Kwok Yin; Sinha, Santosh; Liu, Xiaoxia; Bhat, Smita; Chandraratna, Roshantha A.
Patent: US2005/148590 A1, 2005 ;
Location in patent: Page/Page column 12; 13 ;
反应条件
1: 81.9 percent / AlCl3 / 24 h / Heating 2: 80.4 percent / AlCl3 / 1,2-dichloro-ethane View Scheme
参考文献
Selen Gurkan-Alp; Mumcuoglu, Mine; Andac, Cenk A.; Dayanc, Emre; Cetin-Atalay, Rengul; Buyukbingol, Erdem
European Journal of Medicinal Chemistry, 2012 , vol. 58, p. 346 - 354
反应条件
1: conc. HCl, HCl gas / 0.25 h / 0 °C 2: 81.9 percent / AlCl3 / 24 h / Heating 3: 80.4 percent / AlCl3 / 1,2-dichloro-ethane View Scheme
参考文献
Selen Gurkan-Alp; Mumcuoglu, Mine; Andac, Cenk A.; Dayanc, Emre; Cetin-Atalay, Rengul; Buyukbingol, Erdem
European Journal of Medicinal Chemistry, 2012 , vol. 58, p. 346 - 354
反应条件
1: H2SO4 2: AlCl3 View Scheme
参考文献
Wood,T.F. et al.
Journal of Organic Chemistry, 1963 , vol. 28, p. 2248 - 2255
反应条件
1: AlCl3, aluminium chloride / dichloromethane / 12 h / |Reflux 2: AlCl3, aluminium chloride / dichloromethane / 2 h / |Reflux View Scheme
参考文献
Toyama, Hirozumi; Nakamura, Masaharu; Nakamura, Masahiko; Matsumoto, Yotaro; Nakagomi, Madoka; Hashimoto, Yuichi
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 6 p. 1948 - 1959
反应条件
1: AlCl3 2: AlCl3; 1,2-dichloro-ethane View Scheme
参考文献
Givaudan and Cie.
Patent: DE951267 , 1954 ;
Full Text Show Details
Givaudan Corp.
Patent: US2897237 , 1953 ;
反应条件
aluminium trichloride; 1,2-dichloro-ethane
参考文献
Givaudan and Cie.
Patent: DE951267 , 1954 ;
Full Text Show Details
Givaudan Corp.
Patent: US2897237 , 1953 ;
反应条件
1: sodium borohydride / methanol / 1.5 h / 0 °C 2: phosphorus tribromide / pyridine / diethyl ether; hexane / 2.5 h / 0 - 5 °C 3: diethyl ether; xylene / 48 h / 100 °C 4: 69.3 percent / butylene oxide / 12 h / 65 °C 5: 86 percent / potassium hydroxide / H2O; ethanol / 3 h / 50 °C View Scheme
参考文献
Loeliger; Bollag; Mayer
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 9 - 15
反应条件
bromine in diethyl ether
参考文献
Diaz; Michel; Stella; Charpentier
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 17 p. 2289 - 2294
