2-氨基-3-溴-5-硝基苯甲腈合成路线 （共 9 条）
反应条件
polymer-bound triphenylphosphine; water in dichloromethane T=20°C;
参考文献
Tetrahedron, , vol. 65, # 40 p. 8428 - 8433
反应条件
water in dichloromethane T=20°C;
参考文献
Tetrahedron, , vol. 65, # 40 p. 8428 - 8433
反应条件
bromine in acetic acid 4 h; Heating;
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. 328, # 4 p. 497 - 514
反应条件
sulfuric acid; sodium nitrite in ethanol T=90°C; 13.5 - 36.5 h; Product distribution / selectivity;
参考文献
COMENTIS, INC.; PURDUE RESEARCH FOUNDATION
Patent: WO2009/42694 A1, 2009 ;
Location in patent: Page/Page column 71; 110-111 ;
WO 2009/042694 A1
反应条件
1: 1-amino-2-cyano-4-nitro-6-bromobenzene With nitrosyl-sulphuric acid; sulfuric acid T=5°C; 1 h; 2: N,N-bis(2-hydroxyethyl)-3-acetamidoaniline With aminosulfonic acid in water pH=2 - 3; 2 h; Cooling with ice;
参考文献
MERCK PATENT GMBH; FARRAND, Louise Diane; JAMES, Mark; MARKHAM, Emily Jane; TOPPING, Claire; WILSON, Jonathan Henry
Patent: WO2012/19704 A1, 2012 ;
Location in patent: Page/Page column 107 ;
反应条件
hydrogenchloride; sulfuric acid; aminosulfonic acid; sodium nitrite
1) 2 h, r.t.; 2) water, 6 h; Yield given. Multistep reaction;
参考文献
Thiel, W.; Mayer, R.; Jauer, E.-A.; Modrow, H.; Dost, H.
Journal fuer Praktische Chemie (Leipzig), 1986 , vol. 328, # 4 p. 497 - 514
反应条件
1: CuI / Pd(PPh3)2Cl2 / ethyl acetate; triethylamine; Petroleum ether
2: tetrabutyl ammonium fluoride / tetrahydrofuran; water
3: KOH / ethanol; ethyl acetate; Petroleum ether
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: CuI / Pd(PPh3)2Cl2 / ethyl acetate; triethylamine; Petroleum ether
2: tetrabutyl ammonium fluoride / tetrahydrofuran; water
3: KOH / ethanol; ethyl acetate; Petroleum ether
4: thionyl chloride / methanol; ethyl acetate; Petroleum ether
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
