甲基-2-氧代-7-四氢-4,5,6,7-苯并噻唑合成路线 （共 5 条）
反应条件
pyridine T=50°C; Hantzsch Synthesis;
参考文献
Bayer CropScience AG
Patent: US2009/30024 A1, 2009 ;
Location in patent: Page/Page column 36-37 ;
反应条件
1: SO2Cl2 2: (heating) View Scheme
参考文献
SUNOVION PHARMACEUTICALS, INC.; PSYCHOGENICS INC.; SHAO, Liming; CAMPBELL, John, Emerson; HEWITT, Michael, Charles; CAMPBELL, Una; HANANIA, Taleen, G.
Patent: WO2011/69063 A2, 2011 ;
反应条件
sodium hydroxide 1) EtOH, 1.5 h, 80 deg C, 2) 0.5 h, RT; Yield given. Multistep reaction;
参考文献
Oehler, E.
Monatshefte fuer Chemie, 1993 , vol. 124, # 6/7 p. 763 - 774
参考文献
Muehlstaedt,M.; Bordes,E.
Journal fuer Praktische Chemie (Leipzig), 1963 , vol. 20, p. 285 - 290
反应条件
1: With methanol; sodium hydride in diethyl ether
T=20°C; 16 h;
2: With hydrogenchloride in diethyl ether; water
参考文献
CYCLACEL LIMITED
Patent: WO2005/5438 A1, 2005 ;
Location in patent: Page/Page column 37 ;
WO 2005/005438 A1
