2,5-二甲氧基苯基乙酸合成路线 （共 35 条）
反应条件
1: 92 percent / Br2 / acetic acid / 2 h / 25 °C 2: 85 percent / BH3 / tetrahydrofuran / 8 h / 0 - 25 °C 3: 62 percent / boron tribromide / CH2Cl2 / 22.5 h / Ambient temperature 4: potassium carbonate / acetone / 18 h / Heating 5: acetone / 10.5 h / Heating View Scheme
参考文献
Waldman, Steve R.; Monte, Aaron P.; Bracey, Ann; Nichols, David E.
Tetrahedron Letters, 1996 , vol. 37, # 44 p. 7889 - 7892
参考文献
Huppert
Dtsch. Arch. f. klin. Med., 1899 , vol. 64, p. 137
反应条件
sodium azide; N-ethyl-N,N-diisopropylamine; [bis(2-methoxyethyl)amino]-sulfur trifluoride in dichloromethane; dimethyl sulfoxide T=0 - 20°C; 4 h;
参考文献
Tetrahedron Letters, , vol. 49, # 5 p. 914 - 918
反应条件
sulfuric acid 5 h; Heating;
参考文献
Cannon; Kirschbaum; Amoo; Johnson; Long
Journal of Medicinal Chemistry, 1993 , vol. 36, # 16 p. 2416 - 2419
反应条件
1: thionyl chloride / benzene / 3 h / Heating 2: 77 percent / pyridine / 8 h / Heating View Scheme
参考文献
Kong, Josephine L. Y.; Loach, Paul A.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 737 - 744
反应条件
sodium azide; [bis(acetoxy)iodo]benzene in acetonitrile T=0 - 20°C; 0.25 h;
参考文献
Telvekar, Vikas N.; Sasane, Kulbhushan A.
Synlett, 2010 , # 18 p. 2778 - 2780
反应条件
1: H2SO4 2: LiAlH4 3: Py*HClCrO3, NaOAc View Scheme
参考文献
Gualandi, Andrea; Canestrari, Pietro; Emer, Enrico; Cozzi, Pier Giorgio
Advanced Synthesis and Catalysis, 2014 , vol. 356, # 2-3 p. 528 - 536
反应条件
1: 85 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 0.5 h / Ambient temperature 2: 18 percent / EtSNa / dimethylformamide / 16 h / 115 - 120 °C 3: 79 percent / Ph3P, diethylazodicarboxylate (DEAD) / tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Lal, Kasturi; Ghosh, Subrata; Salomon, Robert G.
Journal of Organic Chemistry, 1987 , vol. 52, # 6 p. 1072 - 1078
反应条件
chloroform; phosphorus pentachloride Durch Eintragen der hergestellten Saeurechlorids in Benzol in aether. Diazomethan-Loesung und Behandeln einer Loesung des Reaktionsprodukts in Chloroform mit wss. HI;
参考文献
Archives of Biochemistry, , vol. 22, p. 288,307
参考文献
Wolkowitz; Dunn
Biochemical Preparations, 1955 , vol. 4, p. 6,11
Full Text Show Details
Abbott; Smith
Journal of Biological Chemistry, 1949 , vol. 179, p. 365,367
