甲基 4-氰基-2-氟苯甲酸合成路线 （共 10 条）
反应条件
zinc cyanide; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=80°C;
参考文献
Penning, Thomas D.; Thomas, Sheela A.; Zhu, Gui-Dong; Gong, Jianchun; Giranda, Vincent L.; Gandhi, Viraj B.
Patent: US2007/112047 A1, 2007 ;
Location in patent: Page/Page column 15-16 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=100°C; 3.5 h;
参考文献
EXELIXIS, INC.
Patent: WO2009/55077 A1, 2009 ;
Location in patent: Page/Page column 447 ;
反应条件
toluene-4-sulfonic acid Reflux;
参考文献
Bartkovitz, David Joseph; Chu, Xin-Jie; Liu, Jin-Jun; Morgan Ross, Tina; Zhang, Zhuming
Patent: US2011/86854 A1, 2011 ;
Location in patent: Page/Page column 44 ;
反应条件
potassium carbonate in acetone 20 h; Reflux;
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: US2010/305052 A1, 2010 ;
Location in patent: Page/Page column 23 ;
反应条件
diiodomethane; isopentyl nitrite; copper(l) iodide in tetrahydrofuran 4 h; Heating / reflux;
参考文献
WO2009/55077 A1, ;
Page/Page column 448 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 12 h;
参考文献
WO2009/124962 A2, ;
Page/Page column 141 ;
WO 2009/124962 A2
反应条件
potassium carbonate; dimethyl sulfate in water; acetone
反应条件
1: in methanol; hexane; toluene 0.166667 h; 2: With acetic acid in methanol; hexane; toluene
参考文献
WO2007/116229 A1, ;
Page/Page column 23 ;
WO 2007/116229 A1
反应条件
1: With sodium tetrahydroborate in methanol 2: With hydrogenchloride; water in methanol pH=3;
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: US2010/305052 A1, 2010 ;
Location in patent: Page/Page column 23 ;
反应条件
hydrogen; acetic acid; nickel in water
T=20°C; 18 h;
参考文献
Giranda, Vincent L.; Penning, Thomas D.; Gandhi, Virajkamar B.; Thomas, Sheela A.; Zhu, Gui-Dong; Gong, Jianchun
Patent: US2007/259937 A1, 2007 ;
Location in patent: Page/Page column 13 ;
