2,6-二溴-4-硝基吡啶合成路线 （共 11 条）
反应条件
phosphorus tribromide in acetonitrile 14 h; Heating;
参考文献
Riemer, Claus; Borroni, Edilio; Levet-Trafit, Bernard; Martin, James R.; Poli, Sonia; Porter, Richard H. P.; Boes, Michael
Journal of Medicinal Chemistry, 2003 , vol. 46, # 7 p. 1273 - 1276
反应条件
1: 79 percent / aq. H2O2; CF3COOH / 3 h / 100 °C 2: 80 percent / HNO3; H2SO4 / 1.5 h / 100 °C 3: 99 percent / PBr3 / acetonitrile / 14 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 7 p. 1273 - 1276
反应条件
1: 80 percent / HNO3; H2SO4 / 1.5 h / 100 °C 2: 99 percent / PBr3 / acetonitrile / 14 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 7 p. 1273 - 1276
反应条件
1: With iron; acetic acid T=90°C; 0.5 h; Heating / reflux; 2: With sodium hydroxide in water pH=12 - 14;
参考文献
PROLYSIS LTD
Patent: WO2009/74810 A1, 2009 ;
Location in patent: Page/Page column 15 ;
WO 2009/074810 A1
反应条件
1: 50 percent / Pd(PPh3)4 / toluene / 16 h / 110 °C 2: 90 percent / hydrazine hydrate / palladium on charcoal / ethanol / Heating View Scheme
参考文献
Fallahpour, Reza-Ali
European Journal of Inorganic Chemistry, 1998 , # 9 p. 1205 - 1207
反应条件
tetra(n-butyl)ammonium hydroxide in tetrahydrofuran; water T=20°C; 72 h;
参考文献
Vidonne, Annick; Philp, Douglas
Tetrahedron, 2008 , vol. 64, # 36 p. 8464 - 8475
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene T=110°C; 16 h;
参考文献
Fallahpour, Reza-Ali
European Journal of Inorganic Chemistry, 1998 , # 9 p. 1205 - 1207
反应条件
Sodium hydride in tetrahydrofuran T=20°C; 2 h;
参考文献
Kureha Kagaku Kogyo Kabushiki Kaisha
Patent: US6339045 B1, 2002 ;
Location in patent: Example 1 ;
反应条件
in tetrahydrofuran; methanol; mineral oil
参考文献
Kureha Kagaku Kogyo Kabushiki Kaisha
Patent: US5691277 A1, 1997 ;
反应条件
in tetrahydrofuran T=40°C; 44 h;
参考文献
Rodriguez-Ubis, Juan Carlos; Sedano, Rosa; Barroso, Gemma; Juanes, Olga; Brunet, Ernesto
Helvetica Chimica Acta, 1997 , vol. 80, # 1 p. 86 - 96
