(5-甲氧基-2-甲基-1H-吲哚-3-基)-乙酸乙酯合成路线 （共 19 条）
反应条件
1.1: [{(η5-C5Me5)RhCl}2(μ-Cl)2]; silver hexafluoroantimonate; copper diacetate; silver carbonate / 1,4-dioxane / 24 h / 110 °C / |Schlenk technique; |Inert atmosphere 2.1: potassium hydroxide / tetrahydrofuran; ethanol / |Reflux 3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 - 20 °C 3.2: 0.5 h 3.3: 24 h View Scheme
参考文献
Gong, Tian-Jun; Cheng, Wan-Min; Su, Wei; Xiao, Bin; Fu, Yao
Tetrahedron Letters, 2014 , vol. 55, # 11 p. 1859 - 1862
反应条件
1.1: potassium hydroxide / tetrahydrofuran; ethanol / |Reflux 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 - 20 °C 2.2: 0.5 h 2.3: 24 h View Scheme
参考文献
Gong, Tian-Jun; Cheng, Wan-Min; Su, Wei; Xiao, Bin; Fu, Yao
Tetrahedron Letters, 2014 , vol. 55, # 11 p. 1859 - 1862
反应条件
1: 1.) triton B, 2.) conc. HCl / 1.) THF, reflux, 10 h, 2.) aq. ethanol, room temp., 1 h 2: conc.H2SO4 / 1 h / Heating View Scheme
参考文献
Garuti; Giovanninetti; Bova; Chiarini
Archiv der Pharmazie, 1988 , vol. 321, # 7 p. 377 - 383
反应条件
1: 42 percent / alumina (neutral) 2: 73 percent / Zn, HOAc / 2 h / 100 °C View Scheme
参考文献
Ishibashi, Hiroyuki; Mita, Naoki; Matsuba, Naoko; Kubo, Tomoko; Nakanishi, Mariko; Ikeda, Masazumi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 21 p. 2821 - 2826
反应条件
1: 5-methoxy-2-methyl-1H-indole-3-acetic acid ethyl ester With potassium tert-butylate in tetrahydrofuran T=0°C; 0.333333 h; Inert atmosphere; 2: 4-chloro-benzoyl chloride in tetrahydrofuran T=25°C; 10 h; Inert atmosphere; 3: With lithium hydroxide hydrate; water in tetrahydrofuran T=25°C; 6 h; Inert atmosphere;
参考文献
Haag, Benjamin A.; Zhang, Zhi-Guang; Li, Jin-Shan; Knochel, Paul
Angewandte Chemie - International Edition, 2010 , vol. 49, # 49 p. 9513 - 9516
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 1 h / -78 °C 1.2: 3 h 2.1: lithium hydroxide hydrate / water / 6 h / 25 °C View Scheme
参考文献
Gong, Tian-Jun; Cheng, Wan-Min; Su, Wei; Xiao, Bin; Fu, Yao
Tetrahedron Letters, 2014 , vol. 55, # 11 p. 1859 - 1862
反应条件
1: 5-methoxy-2-methyl-1H-indole-3-acetic acid ethyl ester With potassium tert-butylate in tetrahydrofuran T=-78°C; 1 h; 2: 4-chloro-benzoyl chloride in tetrahydrofuran 3 h;
参考文献
Gong, Tian-Jun; Cheng, Wan-Min; Su, Wei; Xiao, Bin; Fu, Yao
Tetrahedron Letters, 2014 , vol. 55, # 11 p. 1859 - 1862
反应条件
sodium hydroxide in ethanol 3 h; Ambient temperature;
参考文献
Ishibashi, Hiroyuki; Mita, Naoki; Matsuba, Naoko; Kubo, Tomoko; Nakanishi, Mariko; Ikeda, Masazumi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 21 p. 2821 - 2826
参考文献
Kashimura, Masato; Kikugawa, Yasuo
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 8 p. 2892 - 2894
