2-甲基-4-氨基-6-氯嘧啶合成路线 （共 12 条）
反应条件
ammonia in water; isopropyl alcohol regioselective reaction;
参考文献
Farard, Julien; Loge, Cedric; Pfeiffer, Bruno; Lesur, Brigitte; Duflos, Muriel
Tetrahedron Letters, 2009 , vol. 50, # 41 p. 5729 - 5732
反应条件
1: With trichlorophosphate T=80°C; 1 h; 2: With N,N-dimethyl-formamide T=105°C; 3 h;
参考文献
Astrazeneca AB
Patent: US2009/23719 A1, 2009 ;
Location in patent: Page/Page column 21 ;
US 20090023719 A1
反应条件
ammonia; trichlorophosphate in water
反应条件
1: POCl3 2: methanol; NH3 View Scheme
参考文献
Journal of the Chemical Society, , p. 383,384
Journal of the Chemical Society, , p. 318,321
反应条件
potassium carbonate in N,N-dimethyl-formamide; acetonitrile Microwave irradiationSealed tube;
参考文献
Farard, Julien; Loge, Cedric; Pfeiffer, Bruno; Lesur, Brigitte; Duflos, Muriel
Tetrahedron Letters, 2009 , vol. 50, # 41 p. 5729 - 5732
参考文献
Hirano; Yonemoto
Yakugaku Zasshi, 1956 , vol. 76, p. 234,236
Chem.Abstr., 1956 , p. 13043
参考文献
Maggiolo et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 106
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 24 p. 6061 - 6066
反应条件
hydrogenchloride; palladium on activated charcoal Hydrogenation;
参考文献
Henze et al.
Journal of Organic Chemistry, 1952 , vol. 17, p. 1320,1322
Full Text Show Details
Budesinsky
Collection of Czechoslovak Chemical Communications, 1949 , vol. 14, p. 223,228
Full Text Show Details
Foeldi et al.
Chemische Berichte, 1942 , vol. 75, p. 760
反应条件
4-(N,N-dimethlyamino)pyridine in tetrahydrofuran T=20°C; 3 h; Inert atmosphere;
参考文献
F. HOFFMANN-LA ROCHE AG; BLENCH, Toby; ELLWOOD, Charles; GOODACRE, Simon; LAI, Yingjie; LIANG, Jun; MACLEOD, Calum; MAGNUSON, Steven; TSUI, Vickie; WILLIAMS, Karen; ZHANG, Birong
Patent: WO2012/35039 A1, 2012 ;
Location in patent: Page/Page column 144 ;
WO 2012/035039 A1
