(S)-(-)-N-苄基-1-苯基-乙胺合成路线 （共 37 条）
反应条件
trichlorosilane; [(S)-2-(hydroxydiphenylmethyl)-pyrrolidin-1-yl]-(1-methyl-1H-imidazol-2-yl)methanone in dichloromethane T=0°C; 4 h; Product distribution / selectivity;
参考文献
THE UNIVERSITY OF SHEFFIELD
Patent: WO2009/19469 A2, 2009 ;
Location in patent: Page/Page column 32-34 ;
反应条件
(+)-6-dicyclohexylphosphanyl-2'-diphenylphosphanyl-2-methoxy-1,1'-biphenyl; hydrogen; bis(1,5-cyclooctadiene)-di(iridium(I)-dichloride) in methanol T=20 - 30°C; P=37503.8 Torr; 16 h;
参考文献
EP1609795 A1, ;
Page/Page column 15 ;
反应条件
sodium tetrahydroborate in methanol 1.) RT, 2 h; 2.) 20-28 deg C, 1 h; 3.) RT, 16 h;
参考文献
Qun, Li; Chu, Daniel T. W.; Raye, Kathleen; Claiborne, Akiyo; Seif, Louis; Macri, Bryan; Plattner, Jacob J.
Tetrahedron Letters, 1995 , vol. 36, # 46 p. 8391 - 8394
反应条件
anhydrous magnesium perchlorate; S-(+)-1-benzyl-3-hydroxymethyl-4-methyl-1,4-dihydropyridine in acetonitrile T=45°C; 72 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 29, # 44 p. 5617 - 5620
反应条件
1: benzyl alcohol With 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene in dichloromethane T=20°C; 16 h; 2: (S)-1-phenyl-ethylamine With sodium tris(acetoxy)borohydride in dichloromethane optical yield given as percent eechemoselective reaction;
参考文献
Guerin, Claire; Bellosta, Veronique; Guillamot, Gerard; Cossy, Janine
Organic Letters, 2011 , vol. 13, # 13 p. 3534 - 3537
反应条件
sodium tetrahydroborate
参考文献
Davis, Franklin A.; McCauley, John P.; Chattopadhyay, Sankar; Harakal, Mark E.; Towson, James C.; et al.
Journal of the American Chemical Society, 1987 , vol. 109, # 11 p. 3370 - 3377
反应条件
1: With benzylamine; di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; (+)-6-dicyclohexylphosphanyl-2'-diphenylphosphanyl-2-methoxy-1,1'-biphenyl in methanol T=20°C; 1 h; 2: With hydrogen in methanol T=30°C; P=37503.8 Torr; 15 h; Product distribution / selectivity;
参考文献
WO2006/2731 A1, ;
Page/Page column 19-20 ;
反应条件
2-mercapto benzoic acid; 1,4-di(diphenylphosphino)-butane; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran T=20°C;
参考文献
Lemarie-Audoire, Sandrine; Savignac, Monique; Dupuis, Christophe; Genet, Jean Pierre
Bulletin de la Societe Chimique de France, 1995 , vol. 132, p. 1157 - 1166
反应条件
1: ethanol / 3 h / Heating 2: 186 g / NaBH4 / 72 h / 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 2, # 22 p. 3337 - 3354
反应条件
phosphorus pentoxide in toluene 2 h; Heating;
参考文献
Andres, Celia; Nieto, Javier; Pedrosa, Rafael; Villamanan, Nieves
Journal of Organic Chemistry, 1996 , vol. 61, # 12 p. 4130 - 4135
