4,4-二甲基-1-苯基-1-戊炔-3-酮合成路线 （共 14 条）
反应条件
triethylamine; triphenylphosphine; palladium dichloride in water T=25°C; carbonylative Sonogashira coupling; 12 h;
参考文献
Liang, Bo; Huang, Mengwei; You, Zejin; Xiong, Zhengchang; Lu, Kui; Fathi, Reza; Chen, Jiahua; Yang, Zhen
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 6097 - 6100
反应条件
copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride T=20°C; Sonogashira coupling reaction;
参考文献
Waldo, Jesse P.; Larock, Richard C.
Journal of Organic Chemistry, 2007 , vol. 72, # 25 p. 9643 - 9647
反应条件
copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride in acetonitrile T=60°C; 8 h;
参考文献
Oh, Chang Ho; Reddy, V. Raghava
Tetrahedron Letters, 2004 , vol. 45, # 46 p. 8545 - 8548
反应条件
copper(l) iodide; potassium carbonate in ethylene glycol dimethyl ether T=20°C; P=760 Torr; 2 h;
参考文献
Yu, Chan-Mo; Kweon, Jae-Hong; Ho, Pil-Su; Kang, Sin-Cheol; Lee, Gong Yeal
Synlett, 2005 , # 17 art. no. U23005ST, p. 2631 - 2634
反应条件
1: carbon monoxide; tri-phenyl-antimony With [bis(acetoxy)iodo]benzene in dichloromethane T=20°C; 7 h; 2: 1-(tert-butyl)-2-(trimethylsilyl)acetylene With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; copper(l) iodide in acetonitrile T=50°C; 5 h; Further stages.;
参考文献
Kang, Suk-Ku; Ryu, Hyung-Chul; Hong, Young-Taek
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 7 p. 736 - 739
反应条件
Collins oxidation agent in dichloromethane 0.583333 h; Ambient temperature;
参考文献
Smith, Amos B.; Levenberg, Patricia A.; Suits, Joan Z.
Synthesis, 1986 , # 3 p. 184 - 189
反应条件
anhydrous iron chloride in nitromethane T=-15°C; 6 h; Inert atmosphereSeal tube;
参考文献
Gandeepan, Parthasarathy; Parthasarathy, Kanniyappan; Su, Tsu-Hui; Cheng, Chien-Hong
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 2-3 p. 457 - 468
反应条件
1: 85 percent / 1.) ethylmagnesium bromide / tetrahydrofuran / 2.5 h / Heating 2: Jones's reagent / acetone View Scheme
参考文献
Smith, Amos B.; Levenberg, Patricia A.; Suits, Joan Z.
Synthesis, 1986 , # 3 p. 184 - 189
反应条件
n-butyllithium; boron trifluoride diethyl etherate T=-78°C; 1) THF - hexane, 1 h, then 15 min, 2) 15 min;
参考文献
Brown, Herbert C.; Racherla, Uday S.; Singh Shankar M.
Tetrahedron Letters, 1984 , vol. 25, # 23 p. 2411 - 2414
反应条件
1: 85 percent / 1.) ethylmagnesium bromide / tetrahydrofuran / 2.5 h / Heating 2: Jones's reagent / acetone View Scheme
参考文献
Smith, Amos B.; Levenberg, Patricia A.; Suits, Joan Z.
Synthesis, 1986 , # 3 p. 184 - 189
