5-(4H-1,2,4-噻唑-4-基)-1H-吲哚-3-乙醇合成路线 （共 3 条）
反应条件
1: 91 percent / pTsOH*H2O / toluene / 17 h / Heating 2: 76 percent / 5 N HCl / 1.5 h / 125 °C 3: 67 percent / ICl, CaCO3 / methanol / 16 h / Ambient temperature 4: Na2CO3, MgSO4, Pd(OAc)2 / dimethylformamide / 16 h / 110 °C 5: 5 N HCl / methanol / 19 h / Ambient temperature View Scheme
参考文献
Sternfeld, Francine; Guiblin, Alexander R.; Jelley, Richard A.; Matassa, Victor G.; Reeve, Austin J.; Hunt, Peter A.; Beer, Margaret S.; Heald, Anne; Stanton, Josephine A.; Sohal, Bindi; Watt, Alan P.; Street, Leslie J.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 677 - 690
反应条件
1: 76 percent / 5 N HCl / 1.5 h / 125 °C 2: 67 percent / ICl, CaCO3 / methanol / 16 h / Ambient temperature 3: Na2CO3, MgSO4, Pd(OAc)2 / dimethylformamide / 16 h / 110 °C 4: 5 N HCl / methanol / 19 h / Ambient temperature View Scheme
参考文献
Sternfeld, Francine; Guiblin, Alexander R.; Jelley, Richard A.; Matassa, Victor G.; Reeve, Austin J.; Hunt, Peter A.; Beer, Margaret S.; Heald, Anne; Stanton, Josephine A.; Sohal, Bindi; Watt, Alan P.; Street, Leslie J.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 677 - 690
反应条件
1: Na2CO3, MgSO4, Pd(OAc)2 / dimethylformamide / 16 h / 110 °C 2: 5 N HCl / methanol / 19 h / Ambient temperature View Scheme
参考文献
Sternfeld, Francine; Guiblin, Alexander R.; Jelley, Richard A.; Matassa, Victor G.; Reeve, Austin J.; Hunt, Peter A.; Beer, Margaret S.; Heald, Anne; Stanton, Josephine A.; Sohal, Bindi; Watt, Alan P.; Street, Leslie J.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 677 - 690
