6,7-二甲氧基-1,2,3,4-四氢异喹啉合成路线 （共 60 条）
反应条件
1: 59 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 2: 89 percent / 10percent NaOH / ethanol / 18 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 45, # 5 p. 813 - 819
反应条件
1: 53 percent / toluene / 2 h 2: 63 percent / Zn, glacial acetic acid / dioxane / 4 h / Ambient temperature View Scheme
参考文献
Archiv der Pharmazie (Weinheim, Germany), , vol. 319, # 8 p. 694 - 704
反应条件
1: methanesulphonic acid / acetic anhydride; 1,2-dichloro-ethane / 35 °C 2: 85 percent / methanesulphonic acid / acetic anhydride; 1,2-dichloro-ethane / 35 °C 3: aqueous HCl / 2-methyl-propan-2-ol / 10 h / 75 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1977 - 1982
反应条件
1: methanesulphonic acid / acetic anhydride; 1,2-dichloro-ethane / 35 °C 2: 80 percent / methanesulphonic acid / acetic anhydride; 1,2-dichloro-ethane / 35 °C 3: sodium bis(2-methoxyethoxy)aluminium hydride / benzene / 10 h / 80 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1977 - 1982
反应条件
1: trichlorophosphate / toluene / 2.5 h / 110 °C / Inert atmosphere 2: potassium borohydride; diethylamine / methanol / 24 h / 20 °C View Scheme
参考文献
Medicinal Chemistry, , vol. 8, # 4 p. 711 - 716
反应条件
1: concentrated sulfuric acid; arsenic acid 2: tin; aqueous alcoholic hydrochloric acid View Scheme
参考文献
Journal of the Chemical Society, , vol. 127, p. 1662
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
Journal of Heterocyclic Chemistry, , vol. 47, # 1 p. 54 - 62
反应条件
water; hydrogen bromide T=105°C; 5 h; Product distribution / selectivity;
参考文献
Bauer, Stefanie; Ochoa-Puentes, Cristian; Sun, Qiu; Bause, Manuel; Bernhardt, Guenther; Koenig, Burkhard; Buschauer, Armin
ChemMedChem, 2013 , vol. 8, # 11 p. 1773 - 1778
反应条件
1: 85 percent / TsOH / benzene / Heating View Scheme
参考文献
Gawley, Robert E.; Smith, Gregory A.
Tetrahedron Letters, 1988 , vol. 29, # 3 p. 301 - 302
反应条件
1: toluene / 48 h / Heating View Scheme
参考文献
Gawley, Robert E.; Smith, Gregory A.
Tetrahedron Letters, 1988 , vol. 29, # 3 p. 301 - 302
