5-氟异邻苯二甲酸盐二甲酯合成路线 （共 4 条）
反应条件
1: With hydrogenchloride; sodium nitrite in water T=-5°C; 0.25 h; 2: With hydrofluoroboric acid in water T=0°C; 0.5 h; 3: T=110°C;
参考文献
ASTRA ZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2004/14881 A2, 2004 ;
Location in patent: Page 100-101 ;
WO 2004/014881 A2
反应条件
sulfuric acid 12 h; Heating / reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/71963 A2, 2007 ;
Location in patent: Page/Page column 54 ;
WO 2007/071963 A2
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Boekelheide,V.; Griffin,R.W.
Journal of Organic Chemistry, 1969 , vol. 34, p. 1960 - 1961
反应条件
1: With sodium hydroxide; water in methanol
T=20°C;
2: With hydrogenchloride in water
pH=2;
参考文献
ASTRA ZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2004/14881 A2, 2004 ;
Location in patent: Page 100-101 ;
WO 2004/014881 A2
