(S)-(+)-α-甲基环己烷甲胺合成路线 （共 18 条）
反应条件
hydrogenchloride; hydrogen; Rh/Al2O3 in water T=20°C; Hydrogenation; P=750.06 Torr;
参考文献
Strotmann; Butenschon
Synthetic Communications, 2000 , vol. 30, # 22 p. 4173 - 4176
反应条件
Candida antarctica lipase B in n-heptane T=80°C; 14 h;
参考文献
Journal of Organic Chemistry, , vol. 72, # 18 p. 6918 - 6923
反应条件
1: With transaminase ATA-117; pyridoxal 5'-phosphate; sodium 2-oxopropanoate T=30°C; pH=7.0; 24 h; aq. phosphate bufferResolution of racemateEnzymatic reaction; 2: With [3H]-L-Alanine; transaminase ATA-113 T=30°C; 48 h; aq. phosphate bufferEnzymatic reaction; optical yield given as percent ee;
参考文献
Koszelewski, Dominik; Clay, Dorina; Rozzell, David; Kroutil, Wolfgang
European Journal of Organic Chemistry, 2009 , # 14 p. 2289 - 2292
反应条件
1: With (S)-isopropylidene glycerol 3-carboxy-2-naphthoate in methanol T=20°C; 2: With hydrogenchloride in ethyl acetate Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 13, # 20 p. 2277 - 2282
反应条件
1.1: triethylamine / CH2Cl2 / 0.25 h / 20 °C 1.2: 84 percent / acetic acid / CH2Cl2 / 8 h / 20 °C 2.1: sodium azide / dimethylformamide / 5 h / 100 °C 3.1: hydrogen / Pd View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 12, # 13 p. 1947 - 1951
反应条件
1.1: hydrogen / Pd 2.1: triethylamine / CH2Cl2 / 0.25 h / 20 °C 2.2: 84 percent / acetic acid / CH2Cl2 / 8 h / 20 °C 3.1: sodium azide / dimethylformamide / 5 h / 100 °C 4.1: hydrogen / Pd View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 12, # 13 p. 1947 - 1951
反应条件
1: 1.) CuI, 2.) BF3*Et2O 2: ammonium formate / Pd/C / methanol / 1.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 52, # 38 p. 12571 - 12586
反应条件
1: conc.HCl / tetrahydrofuran 2: 1.) H2, 2.) samarium(II) iodide / 1.) <(COD)Rh(1,2-bis((2R,5R)-2,5-diethylphospholano)-benzene)>+CF3SO3- / 1.) -15 deg C, 36 h, isopropanol, 60 psi; 2.) methanol, THF, 30 min View Scheme
参考文献
Tetrahedron, , vol. 50, # 15 p. 4399 - 4428
参考文献
Tetrahedron Asymmetry, , vol. 12, # 13 p. 1947 - 1951
反应条件
samarium diiodide; hydrogen; 1.) <(COD)Rh(1,2-bis((2R,5R)-2,5-diethylphospholano)-benzene)>+CF3SO3- 1.) -15 deg C, 36 h, isopropanol, 60 psi; 2.) methanol, THF, 30 min; Multistep reaction. Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 50, # 15 p. 4399 - 4428
