(S)-2-(苯氧基甲基)吡咯烷合成路线 （共 6 条）
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 1.5 h;
参考文献
SmithKline Beecham Corporation
Patent: US6514992 B1, 2003 ;
US 6514992 B1
反应条件
in dichloromethane T=20°C; 2 h;
参考文献
THE UNIVERSITY OF EDINBURGH
Patent: WO2009/112845 A1, 2009 ;
Location in patent: Page/Page column 140 ;
WO 2009/112845 A1
反应条件
1.1: 70 percent / pyridine / CH2Cl2 / 16 h / 20 °C 2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 2.2: 78 percent / tetrahydrofuran / 12 h / Heating 3.1: TFA / CH2Cl2 / 1.5 h / 20 °C View Scheme
参考文献
Lee; Long; Murray; Adams; Nuttall; Nadeau; Kikly; Winkler; Sung; Ryan; Levy; Keller; DeWolf Jr.
Journal of Medicinal Chemistry, 2001 , vol. 44, # 12 p. 2015 - 2026
反应条件
1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 1.2: 78 percent / tetrahydrofuran / 12 h / Heating 2.1: TFA / CH2Cl2 / 1.5 h / 20 °C View Scheme
参考文献
Lee; Long; Murray; Adams; Nuttall; Nadeau; Kikly; Winkler; Sung; Ryan; Levy; Keller; DeWolf Jr.
Journal of Medicinal Chemistry, 2001 , vol. 44, # 12 p. 2015 - 2026
反应条件
1.1: 85 percent / Et3N / CH2Cl2 / 16 h / 20 °C 2.1: 70 percent / pyridine / CH2Cl2 / 16 h / 20 °C 3.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 3.2: 78 percent / tetrahydrofuran / 12 h / Heating 4.1: TFA / CH2Cl2 / 1.5 h / 20 °C View Scheme
参考文献
Kopka, Klaus; Faust, Andreas; Keul, Petra; Wagner, Stefan; Breyholz, Hans-Joerg; Hoeltke, Carsten; Schober, Otmar; Schaefers, Michael; Levkau, Bodo
Journal of Medicinal Chemistry, 2006 , vol. 49, # 23 p. 6704 - 6715
反应条件
1: borane 3: TFA / CH2Cl2 View Scheme
参考文献
Elliot, Richard L.; Kopecka, Hana; Gunn, David E.; Lin, Nan-Horng; Garvey, David S.; et al.
Bioorg. Med. Chem. Lett., 1996 , vol. 6, # 19 p. 2283 - 2288
