反应条件
1.1: toluene-4-sulfonic acid / hexane / |Inert atmosphere; |Dean-Stark; |Reflux
2.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.75 h / -78 °C / |Inert atmosphere
2.2: 4 h / -78 - -30 °C / |Inert atmosphere
3.1: potassium hydroxide / methanol; water / 0.5 h / |Inert atmosphere; |Reflux
View Scheme
参考文献
Coutts, Lisa D.; Geiss, William B.; Gregg, Brian T.; Helle, Mark A.; King, Chi-Hsin R.; Itov, Zinovy; Mateo, Mary E.; Meckler, Harold; Zettler, Mark W.; Knutson, Joyce C.
Organic Process Research and Development, 2002 , vol. 6, # 3 p. 246 - 255
