beta-甲基-alpha,alpha-二苯基哌啶-1-丁腈合成路线 （共 6 条）
反应条件
1: α,α-diphenylacetonitrile With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in dimethyl sulfoxide 0.25 h; 2: 1-(2-chloro-propyl)-piperidine; hydrochloride in dimethyl sulfoxide T=40°C; 1 h;
参考文献
Unterhalt; Coesfeld
Scientia Pharmaceutica, 2000 , vol. 68, # 3 p. 229 - 234
反应条件
sodium amide; benzene
参考文献
Bockmuehl; Ehrhart
Justus Liebigs Annalen der Chemie, 1949 , vol. 561, p. 52,76
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Ofner; Walton
Journal of the Chemical Society, 1950 , p. 2158,2162
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Kubota
Kumamoto Medical Journal, 1959 , vol. 12, p. 308,310
Chem.Abstr., 1960 , p. 24711
反应条件
1: nickel catalyst; ethanol / 80 - 100 °C / Hydrogenation 2: benzene; thionyl chloride 3: phenyl lithium; diethyl ether; diethylamine View Scheme
参考文献
Bockmuehl; Ehrhart
Justus Liebigs Annalen der Chemie, 1949 , vol. 561, p. 52,76
反应条件
1: benzene; thionyl chloride 2: phenyl lithium; diethyl ether; diethylamine View Scheme
参考文献
Bockmuehl; Ehrhart
Justus Liebigs Annalen der Chemie, 1949 , vol. 561, p. 52,76
参考文献
Farbw. Hoechst
Patent: DE871761 , 1942 ;
反应条件
2: Ag2O / Erhitzen des Reaktionsprodukts unter vermindertem Druck
View Scheme
参考文献
Ofner; Walton
Journal of the Chemical Society, 1950 , p. 2158,2162
