3,5-二氯-2,4,6-三氟吡啶合成路线 （共 48 条）
反应条件
potassium fluoride in sulfolane T=190°C; 72 h;
参考文献
Chambers, Richard D.; Edwards, Andrew R.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 24 p. 3623 - 3627
反应条件
in neat (no solvent) 400 °C (18 h);;
参考文献
Journal of the Chemical Society, , p. 3573 - 3576
反应条件
in neat (no solvent) autoclave, 470 °C (12 h), 2-fold molar excess of KF;;
参考文献
BE660907 , ;
C.A., , vol. 64, p. 3568
GB1039987 , ;
C.A., , vol. 65, p. 15341
反应条件
in sulfolane byproducts: perfluorochloropyridine; 225 - 235 °C, 2 - 8 h, in presence of 1 - 7 percent alcohol (CH3OH or C2H5OH or C3H7OH or (CH2OH)2 or glycerol or pentaerythrit);;
参考文献
Imperial Chemical Industries Ltd.
Patent: DE2128540 , 1971 ;
C.A., 1972 , vol. 76, p. 59469
反应条件
catalyst: chromium oxide fluoride in gas 560-580 °C (1 h, contact time 4-6 h);;
参考文献
DE2006607 , ;
C.A., , vol. 73, p. 98802
反应条件
cesium fluoride in N,N-dimethyl-formamide T=80°C; 9 h; other reagents; Product distribution;
参考文献
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 33, p. 1975
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 9 p. 2158 - 2159
反应条件
in sulfolane 3,5-Cl2-C5F3N is main product;;
参考文献
Proceedings of the Chemical Society, London, , p. 83 - 83
反应条件
in sulfolane Fluorination at 215 °C (4.5 h) in sulfolane (containing 0.6 vol-percent H2O) gives a turnover of 95.8 percent, product ratio 2-F-C5Cl4N/3-Cl-C5F4N/3,5-Cl2-C5F3N = 3/6/91;;
参考文献
DE1949424 , ;
C.A., , vol. 72, p. 132542
反应条件
in N,N-dimethyl-formamide At 115-120 °C.;
参考文献
US3629422 , ;
C.A., , vol. 76, p. 122962
