反应条件
1.1: 1H-imidazole / dichloromethane / 16 h / 0 - 20 °C 2.1: N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 °C 2.2: 0.5 h / -78 - 20 °C 2.3: 0.33 h 3.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C 5.1: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C View Scheme
参考文献
Cherian, Joseph; Choi, Inhee; Nayyar, Amit; Manjunatha, Ujjini H.; Mukherjee, Tathagata; Lee, Yong Sok; Boshoff, Helena I.; Singh, Ramandeep; Ha, Young Hwan; Goodwin, Michael; Lakshminarayana, Suresh B.; Niyomrattanakit, Pornwaratt; Jiricek, Jan; Ravindran, Sindhu; Dick, Thomas; Keller, Thomas H.; Dartois, Veronique; Barry III, Clifton E.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 16 p. 5639 - 5659
