17356-08-0合成路线 （共 1741 条）
反应条件
1: EtOCHCHCO2Et With N-bromosuccinmide in 1,4-dioxane; water T=-10 - 20°C; 1 h; 2: thiourea in 1,4-dioxane; water T=80°C; 1 h;
参考文献
EP2615092 A1, ;
Paragraph 0095; 0096 ;
反应条件
1: chloroacetic acid ethyl ester; formic acid ethyl ester With sodium in ethanol T=-10 - -5°C; 2: thiourea in ethanol T=80°C; 1.25 h;
参考文献
WO2004/80996 A1, ;
Page 26; 46-47 ;
WO 2004/080996 A1
反应条件
in 1,4-dioxane; water T=80°C; 1 h;
参考文献
Tetrahedron Letters, , vol. 42, # 11 p. 2101 - 2102
反应条件
in water 1.) reflux, 15 min, 2.) RT, 12 h;
参考文献
Heterocycles, , vol. 32, # 4 p. 693 - 701
反应条件
potassium hydrosulphide T=200 - 500°C;
参考文献
Dixon; Taylor
Journal of the Chemical Society, vol. 103, p. 975
参考文献
Gmelin Handbook: K: MVol.4, 5.1, page 894 - 901
参考文献
Gmelin Handbook: K: MVol.4, 5.1, page 894 - 901
反应条件
T=100°C; im geschlossenen Rohr;
参考文献
Reynolds
Journal of the Chemical Society, 1869 , vol. 22, p. 5
Justus Liebigs Annalen der Chemie, 1869 , vol. 150, p. 229
反应条件
1: ethyl (2RS,3SR)-3-methylpropanoate; formic acid ethyl ester With potassium tert-butylate in tetrahydrofuran; diethyl ether T=20°C; 3 h; Inert atmosphere; 2: thiourea in isopropyl alcohol Reflux; 3: With acetic acid in water pH=4;
参考文献
GLAXO GROUP LIMITED; JIN, Yun; WAN, Zehong; ZHANG, Qing
Patent: WO2012/76435 A1, 2012 ;
Location in patent: Page/Page column 49 ;
反应条件
sodium ethanolate in ethanol 7 h; Heating;
参考文献
Spengler; Schunack
Archiv der Pharmazie, 1984 , vol. 317, # 5 p. 425 - 430
