3-氯-2,4,5,6-四氟吡啶合成路线 （共 40 条）
反应条件
1: methanol; tetrahydrofuran / 20 h / 0 - 20 °C
2: H2; Et3N / Pd-C / methanol / 24 h / 2280 Torr
View Scheme
参考文献
Ma, Yongmin; Roy, Sourav; Kong, Xiaole; Chen, Yulin; Liu, Dingyong; Hider, Robert C.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2185 - 2195
反应条件
bromine trifluoride; boron trifluoride in various solvent(s)
T=-3 - 5°C; 0.333333 h;
参考文献
Bardin,V.V.; Furin,G.G.
Journal of Fluorine Chemistry, 1983 , vol. 23, p. 67
反应条件
in not given
molar ratio CaBr2/3-Cl-C5F4N = 4.2/1, 24 h;;
参考文献
Gmelin Handbook: F: PerFHalOrg.5, 4, page 115 - 148
反应条件
1: 99 percent / aq. NH4OH / 5 h / 20 °C
2: 96 percent / Et3N; H2 / 10 percent Pd/C / ethanol / 18 h / 2585.74 Torr
3: 88 percent / conc. H2SO4; KNO3 / 0 - 20 °C
4: 40 percent / conc. H2SO4 / 18 h / 20 °C
5: 98 percent / H2 / Raney Ni / ethanol / 2 h / 1861.73 Torr
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
1: 99 percent / aq. NH4OH / 5 h / 20 °C
2: 96 percent / Et3N; H2 / 10 percent Pd/C / ethanol / 18 h / 2585.74 Torr
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
ammonium hydroxide; zinc
24 h;
参考文献
Selivanova, Galina A.; Gurskaya, Larisa Yu.; Pokrovskii, Leonid M.; Kollegov, Vitaliy F.; Shteingarts, Vitaliy D.
Journal of Fluorine Chemistry, 2004 , vol. 125, # 12 p. 1829 - 1834
反应条件
1: 99 percent / aq. NH4OH / 5 h / 20 °C
2: 96 percent / Et3N; H2 / 10 percent Pd/C / ethanol / 18 h / 2585.74 Torr
3: 88 percent / conc. H2SO4; KNO3 / 0 - 20 °C
4: 40 percent / conc. H2SO4 / 18 h / 20 °C
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
1: 99 percent / aq. NH4OH / 5 h / 20 °C
2: 96 percent / Et3N; H2 / 10 percent Pd/C / ethanol / 18 h / 2585.74 Torr
3: 88 percent / conc. H2SO4; KNO3 / 0 - 20 °C
4: 40 percent / conc. H2SO4 / 18 h / 20 °C
5: 98 percent / H2 / Raney Ni / ethanol / 2 h / 1861.73 Torr
6: 47 percent / 1 h / 100 °C
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
in sulfolane
molar ratio ClC5F4N/CaCl2 = 1/7.5; heating in vacuum (5 Torr) until 100 ml solvent are distilled off; addition of ethyleneglycol and heating to 210 °C (15 min);;
参考文献
Imperial Chemical Industries Ltd.
Patent: GB1367383 , 1974 ;
C.A., 1975 , vol. 82, p. 31266
反应条件
in sulfolane
molar ratio ClC5F4N/CaCl2 = 1/7.5; heating in vacuum (5 Torr) until 100 ml solvent are distilled off; addition of ethyleneglycol and heating to 210 °C (36 min);;
参考文献
Imperial Chemical Industries Ltd.
Patent: GB1367383 , 1974 ;
C.A., 1975 , vol. 82, p. 31266
