3-氯-2,4,5,6-四氟吡啶合成路线 （共 40 条）
反应条件
1: 92 percent / NaBH4 / ethanol / -10 - 0 °C 2: 82 percent / hydrazine monohydrate / ethanol / 20 h / -5 °C 3: 67 percent / aq. CuSO4 / 2 h / Heating View Scheme
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
1: 92 percent / NaBH4 / ethanol / -10 - 0 °C 2: 82 percent / hydrazine monohydrate / ethanol / 20 h / -5 °C 3: 67 percent / aq. CuSO4 / 2 h / Heating 4: 70 percent / HCOONH4; aq. AcOH / Pd/C / 2 h / 25 °C View Scheme
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
sodium tetrahydroborate in ethanol T=-10 - 0°C;
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
water; copper; zinc in N,N-dimethyl-formamide T=70°C; 8 h; Title compound not separated from byproducts;
参考文献
Krasnov, V. I.; Platonov, V. E.
Russian Journal of Organic Chemistry, 1993 , vol. 29, # 5.2 p. 895 - 896
Zhurnal Organicheskoi Khimii, 1993 , vol. 29, # 5 p. 1078 - 1079
反应条件
zinc in water; N,N-dimethyl-formamide 20 h; Heating;
参考文献
Krasnov; Platonov
Russian Journal of Organic Chemistry, 2000 , vol. 36, # 10 p. 1488 - 1499
反应条件
methanol; phosphorous acid trisdiethylamide in diethyl ether 0.5 h; Title compound not separated from byproducts;
参考文献
Bardin
Russian Chemical Bulletin, 1997 , vol. 46, # 8 p. 1434 - 1436
反应条件
methanol in diethyl ether 0.5 h; Title compound not separated from byproducts;
参考文献
Bardin
Russian Chemical Bulletin, 1997 , vol. 46, # 8 p. 1434 - 1436
反应条件
ammonium hydroxide T=20°C; 5 h;
参考文献
Sartorelli, Alan C.; Cheng, Yung-Chi; Liu, Mao-Chin
Patent: US2004/116362 A1, 2004 ;
Location in patent: Page/Page column 11; Figure 1 ;
反应条件
ammonium hydroxide; zinc 24 h;
参考文献
Selivanova, Galina A.; Gurskaya, Larisa Yu.; Pokrovskii, Leonid M.; Kollegov, Vitaliy F.; Shteingarts, Vitaliy D.
Journal of Fluorine Chemistry, 2004 , vol. 125, # 12 p. 1829 - 1834
参考文献
Gmelin Handbook: F: PerFHalOrg.5, 4.1.1.3, page 180 - 219
