2-氯-4’-硝基乙酰苯胺合成路线 （共 23 条）
反应条件
1: 92 percent / methanol / 0 - 20 °C 2: 84 percent / ammonium formate; Pd/C / dimethylformamide / 16 h / 20 °C View Scheme
参考文献
Rao, Guo-Wu; Xu, Geng-Jie; Wang, Jian; Jiang, Xu-Liang; Li, Hai-Bo
ChemMedChem, 2013 , vol. 8, # 6 p. 928 - 933
反应条件
thionyl chloride in methanol 0.05 h; Reflux;
参考文献
Wang, Gong-Bao; Wang, Lin-Fa; Li, Chao-Zhang; Sun, Jing; Zhou, Guang-Ming; Yang, Da-Cheng
Research on Chemical Intermediates, 2012 , vol. 38, # 1 p. 77 - 89
参考文献
Pfeiffer; Saure
Journal fuer Praktische Chemie (Leipzig), 1941 , vol. <2>157, p. 97,120
反应条件
in tetrahydrofuran
T=50°C;
参考文献
Tala, Satishkumar D.; Ou, Tai-Hsin; Lin, Yi-Wen; Tala, Kiranben S.; Chao, Shu-Hsin; Wu, Ming-Hsi; Tsai, Tung-Hu; Kakadiya, Rajesh; Suman, Sharda; Chen, Ching-Huang; Lee, Te-Chang; Su, Tsann-Long
European Journal of Medicinal Chemistry, 2014 , vol. 76, p. 155 - 169
反应条件
1: 82 percent / methanol / 0 - 20 °C
2: 70 percent / ammonium formate; Pd/C / dimethylformamide / 16 h / 20 °C
View Scheme
参考文献
Tala, Satishkumar D.; Ou, Tai-Hsin; Lin, Yi-Wen; Tala, Kiranben S.; Chao, Shu-Hsin; Wu, Ming-Hsi; Tsai, Tung-Hu; Kakadiya, Rajesh; Suman, Sharda; Chen, Ching-Huang; Lee, Te-Chang; Su, Tsann-Long
European Journal of Medicinal Chemistry, 2014 , vol. 76, p. 155 - 169
反应条件
1.1: 80 percent / methanol / 0 - 20 °C
2.1: 90 percent / ammonium formate; Pd/C / dimethylformamide / 16 h / 20 °C
3.1: aq. HCl; t-BuONO / tetrahydrofuran / 1 h / 0 °C
3.2: 90 percent / NaN3 / tetrahydrofuran; H2O / 0 - 20 °C
View Scheme
参考文献
Moorhouse, Adam D.; Santos, Ana Mafalda; Gunaratnam, Mekala; Moore, Michael; Neidle, Stephen; Moses, John E.
Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 15972 - 15973
反应条件
1.1: 82 percent / methanol / 0 - 20 °C
2.1: 70 percent / ammonium formate; Pd/C / dimethylformamide / 16 h / 20 °C
3.1: aq. HCl; t-BuONO / tetrahydrofuran / 1 h / 0 °C
3.2: 69 percent / NaN3 / tetrahydrofuran; H2O / 0 - 20 °C
View Scheme
参考文献
Moorhouse, Adam D.; Santos, Ana Mafalda; Gunaratnam, Mekala; Moore, Michael; Neidle, Stephen; Moses, John E.
Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 15972 - 15973
反应条件
1.1: 91 percent / methanol / 0 - 20 °C
2.1: 97 percent / ammonium formate; Pd/C / dimethylformamide / 16 h / 20 °C
3.1: aq. HCl; t-BuONO / tetrahydrofuran / 1 h / 0 °C
3.2: 84 percent / NaN3 / tetrahydrofuran; H2O / 0 - 20 °C
View Scheme
参考文献
Moorhouse, Adam D.; Santos, Ana Mafalda; Gunaratnam, Mekala; Moore, Michael; Neidle, Stephen; Moses, John E.
Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 15972 - 15973
反应条件
1.1: 98 percent / methanol / 0 - 20 °C
2.1: 91 percent / ammonium formate; Pd/C / dimethylformamide / 16 h / 20 °C
3.1: aq. HCl; t-BuONO / tetrahydrofuran / 1 h / 0 °C
3.2: 84 percent / NaN3 / tetrahydrofuran; H2O / 0 - 20 °C
View Scheme
参考文献
Moorhouse, Adam D.; Santos, Ana Mafalda; Gunaratnam, Mekala; Moore, Michael; Neidle, Stephen; Moses, John E.
Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 15972 - 15973
反应条件
1.1: 92 percent / methanol / 0 - 20 °C
2.1: 84 percent / ammonium formate; Pd/C / dimethylformamide / 16 h / 20 °C
3.1: aq. HCl; t-BuONO / tetrahydrofuran / 1 h / 0 °C
3.2: 72 percent / NaN3 / tetrahydrofuran; H2O / 0 - 20 °C
View Scheme
参考文献
Moorhouse, Adam D.; Santos, Ana Mafalda; Gunaratnam, Mekala; Moore, Michael; Neidle, Stephen; Moses, John E.
Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 15972 - 15973
