反应条件
1: 1.) dimethyldioxirane, 2.) TsOH / 1.) acetone, CH2Cl2, 0 deg C, 12 h, 2.) CH2Cl2, 0 deg C, 20 min
2: conc. HCl / acetic acid / 2 h / Ambient temperature
3: K2CO3 / acetone / Heating
4: AlBr3 / acetonitrile / 0.67 h / 0 °C
5: H2 / 10percent Pd/C / methanol; ethyl acetate
View Scheme
参考文献
Horie; Kawamura; Yamamoto; Yamashita
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 12 p. 2054 - 2063