2-羟基-5-硝基苯甲酸甲酯合成路线 （共 37 条）
反应条件
hydrogenchloride in pyridine
参考文献
Pharmacia AB
Patent: US4528367 A1, 1985 ;
反应条件
1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 20 °C
2: hydroxylamine / methanol; water / 20 °C
3: palladium 10 on activated carbon; hydrogen / ethanol / 1.5 h / 2585.81 Torr
View Scheme
参考文献
Nogra Pharma Limited; NACCARI, Giancarlo; BARONI, Sergio
Patent: EP1910275 B1, 2013 ;
反应条件
1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / |Cooling with ice
2.1: lithium hydroxide hydrate; water / tetrahydrofuran / 20 °C
2.2: pH 1
3.1: palladium 10 on activated carbon; hydrogen / ethanol / 2 h / 2585.81 Torr
View Scheme
参考文献
Nogra Pharma Limited; NACCARI, Giancarlo; BARONI, Sergio
Patent: EP1910275 B1, 2013 ;
反应条件
1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 20 °C
2: hydroxylamine / methanol; water / 20 °C
View Scheme
参考文献
Nogra Pharma Limited; NACCARI, Giancarlo; BARONI, Sergio
Patent: EP1910275 B1, 2013 ;
反应条件
1: methyl-2-hydroxy-5-nitro-benzoate With sodium hydride in DMF (N,N-dimethyl-formamide)
T=0 - 20°C; 0.5 h;
2: benzyl bromide in DMF (N,N-dimethyl-formamide)
T=70°C; 3 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1437344 A1, 2004 ;
Location in patent: Page 69 ;
反应条件
sulfuric acid
Acetylation; 3 h; Heating;
参考文献
Sztaricskai, Ferenc; Takacs, Ildiko E.; Pusztai, Ferenc; Szabo, Gabor; Csipo, Istvan
Archiv der Pharmazie, 1999 , vol. 332, # 9 p. 321 - 326
反应条件
hydroxylamine hydrochloride; triethylamine in water; dimethyl sulfoxide
T=50°C; 3 h;
参考文献
Kozlov, Maxim V.; Kleymenova, Alla A.; Romanova, Lyudmila I.; Konduktorov, Konstantin A.; Smirnova, Olga A.; Prasolov, Vladimir S.; Kochetkov, Sergey N.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 21 p. 5936 - 5940
