4-(6-甲氧基-2-苯基-3,4-二氢萘并醛烯-1-基)苯酚合成路线 （共 9 条）
反应条件
1: 1-(p-hydroxyphenyl)-6-methoxy-2-phenyl-3,4-dihydronaphthalene With sodium hydride in N,N-dimethyl-formamide T=20°C; 0.333333 h; 2: N-(2-chloroethyl)-pyrrolidine hydrochloride in N,N-dimethyl-formamide T=50°C; 11 h;
参考文献
Nakata, Kenya; Sano, Yoshiyuki; Shiina, Isamu
Molecules, 2010 , vol. 15, # 10 p. 6773 - 6794
反应条件
sodium hydride in N,N-dimethyl-formamide T=50°C;
参考文献
Sano, Yoshiyuki; Nakata, Kenya; Otoyama, Takafumi; Umeda, Sei; Shiina, Isamu
Chemistry Letters, 2007 , vol. 36, # 1 p. 40 - 41
反应条件
hydrogen; palladium on activated charcoal in acetic acid
参考文献
Lednicer,D. et al.
Journal of Medicinal Chemistry, 1967 , vol. 10, p. 1051 - 1054
反应条件
1: AcOH / aq. ethanol
2: aq. H2SO4
3: (i) Zn-Hg, aq. HCl, (ii) HF
4: (i) Mg, THF, (ii) /BRN= 1472433/, (iii) aq. HCl, MeOH
View Scheme
参考文献
Lednicer; Lyster; Aspergren; Duncan
Journal of medicinal chemistry, 1966 , vol. 9, # 2 p. 172 - 176
反应条件
1: (i) aq. NaOH, EtOH, (ii) /BRN= 471223/
2: AcOH / aq. ethanol
3: aq. H2SO4
4: (i) Zn-Hg, aq. HCl, (ii) HF
5: (i) Mg, THF, (ii) /BRN= 1472433/, (iii) aq. HCl, MeOH
View Scheme
参考文献
Lednicer; Lyster; Aspergren; Duncan
Journal of medicinal chemistry, 1966 , vol. 9, # 2 p. 172 - 176
反应条件
1: aq. H2SO4
2: (i) Zn-Hg, aq. HCl, (ii) HF
3: (i) Mg, THF, (ii) /BRN= 1472433/, (iii) aq. HCl, MeOH
View Scheme
参考文献
Lednicer; Lyster; Aspergren; Duncan
Journal of medicinal chemistry, 1966 , vol. 9, # 2 p. 172 - 176
反应条件
magnesium
1.) THF, 2.) THF, room temp, 1 h; reflux, 1 h; Yield given. Multistep reaction;
参考文献
Bindal, Rajeshwar D.; Durani, S.; Kapil, Randhir S.; Anand, Nitya
Synthesis, 1982 , # 5 p. 405 - 407
反应条件
1: (i) Zn-Hg, aq. HCl, (ii) HF
2: (i) Mg, THF, (ii) /BRN= 1472433/, (iii) aq. HCl, MeOH
View Scheme
参考文献
Lednicer; Lyster; Aspergren; Duncan
Journal of medicinal chemistry, 1966 , vol. 9, # 2 p. 172 - 176
反应条件
(i) Mg, THF, (ii) /BRN= 1472433/, (iii) aq. HCl, MeOH; Multistep reaction;
参考文献
Lednicer; Lyster; Aspergren; Duncan
Journal of medicinal chemistry, 1966 , vol. 9, # 2 p. 172 - 176
