(S)-(-)-α-甲氧基-α-(三氟甲基)苯乙酸合成路线 （共 24 条）
反应条件
1: 98 percent / AD-mix α / 2-methyl-propan-2-ol; H2O / 2 h / 20 °C 2: 96 percent / DMAP; Et3N / CH2Cl2 / 2 h / 20 °C 3: 96 percent / t-BuOK / acetonitrile / 12 h / 20 °C 4: 100 percent / TBAF / acetonitrile / 4 h / 20 °C 5: 78 percent / TEMPO; NaClO; NaClO2 / acetonitrile; aq. phosphate buffer / 4 h / 55 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 4 p. 503 - 510
反应条件
1: 96 percent / DMAP; Et3N / CH2Cl2 / 2 h / 20 °C 2: 96 percent / t-BuOK / acetonitrile / 12 h / 20 °C 3: 100 percent / TBAF / acetonitrile / 4 h / 20 °C 4: 78 percent / TEMPO; NaClO; NaClO2 / acetonitrile; aq. phosphate buffer / 4 h / 55 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 4 p. 503 - 510
反应条件
1: 100 percent / TBAF / acetonitrile / 4 h / 20 °C 2: 78 percent / TEMPO; NaClO; NaClO2 / acetonitrile; aq. phosphate buffer / 4 h / 55 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 4 p. 503 - 510
反应条件
1: 96 percent / t-BuOK / acetonitrile / 12 h / 20 °C 2: 100 percent / TBAF / acetonitrile / 4 h / 20 °C 3: 78 percent / TEMPO; NaClO; NaClO2 / acetonitrile; aq. phosphate buffer / 4 h / 55 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 4 p. 503 - 510
反应条件
1: 35 percent aq. H2O2, NaOH / ethanol; H2O / 1.) 1 h, 0 deg C, 2.) 2 h, reflux 2: NaOH / H2O / 5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 42, # 2 p. 547 - 552
反应条件
sodium hydroxide in water 5 h; Heating;
参考文献
Tetrahedron, , vol. 42, # 2 p. 547 - 552
反应条件
RuO4; potassium meta-periodate in tetrachloromethane; water; acetonitrile
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 8 p. 947 - 949
反应条件
1: NaH 2: RuO4, KIO4 / H2O; CCl4; acetonitrile View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 8 p. 947 - 949
反应条件
Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 55, # 13 p. 4216 - 4218
反应条件
hydrolysis; Yield given. Yields of byproduct given;
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 36, # 8 p. 499 - 504
