1-氧杂环十四烷-2-酮合成路线 （共 44 条）
反应条件
toluene-4-sulfonic acid in benzene
24 h; Heating;
参考文献
Wasserman, Harry H.; Gambale, Ronald J.; Pulwer, Mitchell J.
Tetrahedron Letters, 1981 , vol. 22, # 18 p. 1737 - 1740
反应条件
tri-n-butyltin methoxide in octane
Heating;
参考文献
White; Green; Fleming
Tetrahedron Letters, 1993 , vol. 34, # 22 p. 3515 - 3518
反应条件
in tetrachloromethane
12 h; Heating;
参考文献
Torra, Nuria; Urpi, Felix; Vilarrasa, Jaume
Tetrahedron, 1989 , vol. 45, # 3 p. 863 - 868
反应条件
1: 1.) p-toluene-sulfonic acid, 2.) NaI / 1.) THF, RT, 1 h, 2.) RT, 24 h, acetone
2: 48 percent / n-BuLi, diisopropylamine / tetrahydrofuran; hexane / -78 degC, 30 min and RT, 4 h
3: 1.) O2, 2.) p-toluenesulfonic acid / 1.) Sensitox / 1.) CH2Cl2, 30 min, irradiation, 2.) benzene, 24 h, reflux
View Scheme
参考文献
Wasserman, Harry H.; Gambale, Ronald J.; Pulwer, Mitchell J.
Tetrahedron, 1981 , vol. 37, # 23 p. 4059 - 4067
反应条件
1: 1.) p-toluene-sulfonic acid, 2.) NaI / 1.) THF, RT, 1 h, 2.) RT, 24 h, acetone
2: 48 percent / n-BuLi, diisopropylamine / tetrahydrofuran; hexane / -78 degC, 30 min and RT, 4 h
3: 1.) O2, 2.) p-toluenesulfonic acid / 1.) Sensitox / 1.) CH2Cl2, 30 min, irradiation, 2.) benzene, 24 h, reflux
View Scheme
参考文献
Wasserman, Harry H.; Gambale, Ronald J.; Pulwer, Mitchell J.
Tetrahedron, 1981 , vol. 37, # 23 p. 4059 - 4067
反应条件
in tetrachloromethane
6 h; Heating;
参考文献
Torra, Nuria; Urpi, Felix; Vilarrasa, Jaume
Tetrahedron, 1989 , vol. 45, # 3 p. 863 - 868
反应条件
1: 95 percent / toluene / 48 h / Heating
2: 0.1 N HCl, THF / 1 h / Ambient temperature
3: LiOH, 85 percent H3PO4, glacial acetic acid, B(OH)3 / toluene; H2O
4: LiOH, 85 percent H3PO4, glacial acetic acid, B(OH)3 / toluene; H2O / pH 8.4
5: 99 percent / H2 / Pd/C
View Scheme
参考文献
Bestmann, Hans Juergen; Schobert, Rainer
Angewandte Chemie, 1983 , vol. 95, # 10 p. 810 - 811
反应条件
1: 0.1 N HCl, THF / 1 h / Ambient temperature
2: LiOH, 85 percent H3PO4, glacial acetic acid, B(OH)3 / toluene; H2O
3: LiOH, 85 percent H3PO4, glacial acetic acid, B(OH)3 / toluene; H2O / pH 8.4
4: 99 percent / H2 / Pd/C
View Scheme
参考文献
Bestmann, Hans Juergen; Schobert, Rainer
Angewandte Chemie, 1983 , vol. 95, # 10 p. 810 - 811
反应条件
oxygen; toluene-4-sulfonic acid; Sensitox
1.) CH2Cl2, 30 min, irradiation, 2.) benzene, 24 h, reflux; Yield given. Multistep reaction;
参考文献
Wasserman, Harry H.; Gambale, Ronald J.; Pulwer, Mitchell J.
Tetrahedron, 1981 , vol. 37, # 23 p. 4059 - 4067
反应条件
1: 1.) LDA / 1.) THF, -78 deg C, 1.5h, 2.) -78 deg C, 10 min
2: 2N HCl / tetrahydrofuran / 3 h / 60 °C
3: oxygen, Sensitox (Rose Bengal polymer) / CH2Cl2 / 0.5 h / Irradiation
4: 75 percent / p-toluenesulfonic acid / benzene / 24 h / Heating
View Scheme
参考文献
Wasserman, Harry H.; Gambale, Ronald J.; Pulwer, Mitchell J.
Tetrahedron Letters, 1981 , vol. 22, # 18 p. 1737 - 1740
