(S)-(+)-扁桃酸合成路线 （共 229 条）
反应条件
sulfuric acid in ethanol T=70°C; 23 h; Inert atmosphere;
参考文献
Ren, Qin; Tsunaba, Kana; Kitamura, Yoshiaki; Nakashima, Remi; Shibada, Aya; Ikeda, Masato; Kitade, Yukio
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 6 p. 1519 - 1522
反应条件
hydrogen; acetic acid; Rh/Al2O3 in methanol P=2280 Torr; 10 h;
参考文献
The Procter and Gamble Company
Patent: US4331818 A1, 1982 ;
反应条件
1: borane 2: 82 percent / diethoxytriphenylphosphorane / CH2Cl2 / Heating View Scheme
参考文献
Robinson, Philip L.; Barry, Carey N.; Bass, S. Woody; Jarvis, Susan E.; Evans, Slayton A.
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5396 - 5398
反应条件
1: 60 percent / acetone 2: 88 percent / 2N NaOH / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Fitzi, Robert; Seebach, Dieter
Tetrahedron, 1988 , vol. 44, # 17 p. 5277 - 5292
反应条件
1.1: 60 percent / p-TsOH; H2SO4 / pentane / 24 h / Heating 2.1: lithium diisopropylamine / hexane; diethyl ether / 0.5 h / -78 °C 2.2: hexane; diethyl ether / 2 h / -78 °C 3.1: aq. KOH / methanol / 3 h / Heating View Scheme
参考文献
Journal of Chemical Research, , # 12 p. 816 - 817
反应条件
2: SOCl2
4: LAH / tetrahydrofuran / Heating
View Scheme
参考文献
Cocolas; Robinson; Dewey; Spaulding
Journal of pharmaceutical sciences, 1971 , vol. 60, # 11 p. 1749 - 1752
反应条件
1: 1) TFA, 2) LiAlH4 / 1) 0 deg C, 22 h, r.t., 3 h, 2) Et2O, reflux, 14 h
2: 89 percent / KOH / dimethylsulfoxide / 1.5 h / Ambient temperature
3: 97 percent / aq. HCl / tetrahydrofuran / 22 h
View Scheme
参考文献
Brunner; Rueckert
Monatshefte fur Chemie, 1998 , vol. 129, # 4 p. 339 - 354
反应条件
in acetonitrile
T=130°C; 0.0833333 h; Microwave irradiation;
参考文献
Chighine, Alessandra; Crosignani, Stefano; Arnal, Marie-Claire; Bradley, Mark; Linclau, Bruno
Journal of Organic Chemistry, 2009 , vol. 74, # 13 p. 4753 - 4762
反应条件
in acetonitrile
T=130°C; 0.0833333 h; Microwave irradiation;
参考文献
Chighine, Alessandra; Crosignani, Stefano; Arnal, Marie-Claire; Bradley, Mark; Linclau, Bruno
Journal of Organic Chemistry, 2009 , vol. 74, # 13 p. 4753 - 4762
