2-甲基-4-苯基-3-丁炔-2-醇合成路线 （共 97 条）
反应条件
calcium triflimide; nBu4NPF6 in dichloromethane
T=20°C; Friedel Crafts alkylation; 2 h; regioselective reaction;
参考文献
Niggemann, Meike; Meel, Matthias J.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 21 p. 3684 - 3687
反应条件
cerium trifluoromethanesulfonate in nitromethane
T=80°C; Friedel-Crafts reaction; 1.75 h; regioselective reaction;
参考文献
Silveira, Claudio C.; Mendes, Samuel R.; Martins, Guilherme M.
Tetrahedron Letters, 2012 , vol. 53, # 13 p. 1567 - 1570
反应条件
1: 2-hydroxy-2-methyl-4-phenyl-3-butyne With (o,o'-biphenylenedioxy)methylaluminium in hexane; dichloromethane
T=20°C; 0.5 h;
2: chloral in hexane; dichloromethane
T=20°C; Meerwein-Ponndorf-Verley alkynylation; 5 h;
参考文献
Ooi, Takashi; Miura, Tomoya; Ohmatsu, Kohsuke; Saito, Akira; Maruoka, Keiji
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 22 p. 3312 - 3319
反应条件
(o,o'-biphenylenedioxy)methylaluminium
1.) CH2Cl2, RT, 30 min, 2.) CH2Cl2, RT, 5 h; Yield given. Multistep reaction;
参考文献
Ooi; Miura; Maruoka
Journal of the American Chemical Society, 1998 , vol. 120, # 41 p. 10790 - 10791
反应条件
{(Pd{Fe(.eta.5-C5H5)(.eta.5-C5H3C(CH3)=NC6H4CH3-4)}(.mu.-Cl))2}; potassium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in acetonitrile
T=110°C; 16 h; Inert atmosphere;
参考文献
Hu, Hao; Yang, Fan; Wu, Yangjie
Journal of Organic Chemistry, 2013 , vol. 78, # 20 p. 10506 - 10511
反应条件
sodium hydroxide; copper(l) iodide in butan-1-ol
24 h; Heating;
参考文献
Kang, Suk-Ku; Yoon, Seok-Keun; Kim, Young-Mook
Organic Letters, 2001 , vol. 3, # 17 p. 2697 - 2699
反应条件
{(Pd{Fe(.eta.5-C5H5)(.eta.5-C5H3C(CH3)=NC6H4CH3-4)}(.mu.-Cl))2}; potassium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in acetonitrile
T=110°C; 16 h; Inert atmosphere; Reagent/catalystSolventTemperature;
参考文献
Hu, Hao; Yang, Fan; Wu, Yangjie
Journal of Organic Chemistry, 2013 , vol. 78, # 20 p. 10506 - 10511
