(1S,3R)-甲基-1,2,3,4-四氢-1-(3,4-亚甲二氧基苯基)-9H-吡啶并[3,4-b]吲哚-3-羧酸酯合成路线 (共 15 条)
反应条件
palladium 10 on activated carbon; hydrogen in acetonitrile T=60°C; P=798.054 - 836.056 Torr; 8 h;
参考文献
Dong, Jing; Meng, Tian-Zhuo; Shi, Xiao-Xin; Zou, Wen-Hui; Lu, Xia
Tetrahedron Asymmetry, 2013 , vol. 24, # 15-16 p. 883 - 893
反应条件
palladium 10 on activated carbon; hydrogen in acetonitrile T=60°C; P=798.054 - 836.056 Torr; 8 h;
参考文献
Dong, Jing; Meng, Tian-Zhuo; Shi, Xiao-Xin; Zou, Wen-Hui; Lu, Xia
Tetrahedron Asymmetry, 2013 , vol. 24, # 15-16 p. 883 - 893
反应条件
acetic acid; benzoic acid T=0 - 5°C; Pictet-Spengler reaction; 16 h;
参考文献
Tetrahedron Asymmetry, , vol. 19, # 4 p. 435 - 442
反应条件
trifluoroacetic acid in dichloromethane T=25°C; Pictet-Spengler cyclization; 20 h;
参考文献
Jiang, Weiqin; Zhang, Xuqing; Sui, Zhihua
Organic letters, 2003 , vol. 5, # 1 p. 43 - 46
反应条件
trifluoroacetic acid in methanol; dichloromethane T=20°C; Pictet-Spengler reaction; 60 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 6 p. 1505 - 1515
反应条件
hydrogenchloride in water 24 h; Reflux;
参考文献
EP2107059 A1, ;
Page/Page column 7-8 ;
反应条件
1: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 h / 81 °C 2: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 18 h / 81 °C / |Inert atmosphere 3: palladium 10 on activated carbon; hydrogen / acetonitrile / 8 h / 60 °C / 798.05 - 836.06 Torr View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 24, # 15-16 p. 883 - 893
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 18 h / 81 °C / |Inert atmosphere 2: palladium 10 on activated carbon; hydrogen / acetonitrile / 8 h / 60 °C / 798.05 - 836.06 Torr View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 24, # 15-16 p. 883 - 893
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 18 h / 81 °C / |Inert atmosphere 2: palladium 10 on activated carbon; hydrogen / acetonitrile / 8 h / 60 °C / 798.05 - 836.06 Torr View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 24, # 15-16 p. 883 - 893
反应条件
carbonic acid dimethyl ester T=20°C; 23 h; Ionic liquid;
参考文献
RSC Advances, , vol. 4, # 3 p. 1204 - 1211