2,7-二溴-9,9'-螺二芴合成路线 （共 13 条）
反应条件
hydrogenchloride in water; acetic acid 12 h; Heating / reflux;
参考文献
EP1777227 A1, ;
Page/Page column 6-7 ;
反应条件
1: diethyl ether / 3 h / Heating 2: conc. H2SO4 / 3 h View Scheme
参考文献
Journal of the American Chemical Society, , vol. 124, # 39 p. 11576 - 11577
反应条件
ammonium chloride; magnesium in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; diethyl ether; acetic acid
反应条件
1: diethyl ether / 3 h / Heating 2: conc. H2SO4 / 3 h View Scheme
参考文献
Journal of the American Chemical Society, , vol. 124, # 39 p. 11576 - 11577
反应条件
1.1: Mg / diethyl ether / Heating 1.2: diethyl ether / Heating 2.1: 10.0 g / conc. HCl / acetic acid / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 67, # 14 p. 4924 - 4936
反应条件
1: 1-bromo-2-phenylbenzene With magnesium in tetrahydrofuran 3 h; Heating; 2: 2,7-dibromo-9-fluorenone in tetrahydrofuran Heating; 3: With hydrogenchloride; acetic acid Heating; Further stages.;
参考文献
Synthetic Communications, , vol. 38, # 12 p. 1888 - 1895
反应条件
1.1: N-bromosuccinmide / 4-methyl-1,3-dioxolan-2-one / 3 h / Reflux 2.1: chromium(VI) oxide; acetic acid / 1 h / 120 °C 3.1: iodine; magnesium / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 3.2: 20 °C / Inert atmosphere; Reflux 4.1: hydrogenchloride; acetic acid / water / 2.5 h / 140 °C View Scheme
参考文献
Macromolecules, , vol. 43, # 24 p. 10355 - 10365
反应条件
1.1: 5 Pd(II)/C(eggshell); hydrogen / ethyl acetate / 24 h / 20 °C / 3800.26 Torr 2.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 °C 2.2: 0 - 20 °C 3.1: iodine; magnesium / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 3.2: 20 °C / Inert atmosphere; Reflux 4.1: hydrogenchloride; acetic acid / water / 2.5 h / 140 °C View Scheme
参考文献
Macromolecules, , vol. 43, # 24 p. 10355 - 10365
反应条件
1.1: chromium(VI) oxide; acetic acid / 1 h / 120 °C 2.1: iodine; magnesium / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 2.2: 20 °C / Inert atmosphere; Reflux 3.1: hydrogenchloride; acetic acid / water / 2.5 h / 140 °C View Scheme
参考文献
Macromolecules, , vol. 43, # 24 p. 10355 - 10365
反应条件
1.1: iodine; magnesium / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 1.2: 20 °C / Inert atmosphere; Reflux 2.1: hydrogenchloride; acetic acid / water / 2.5 h / 140 °C View Scheme
参考文献
Macromolecules, , vol. 43, # 24 p. 10355 - 10365
