1-甲基-1,2-环氧环己烷合成路线 （共 60 条）
反应条件
1: HCl / diethyl ether / 2 h / 13 °C
2: POCl3, pyridine
View Scheme
参考文献
Vereshchagin, A. N.; Kovylyaeva, G. I.; Bakaleinik, G. A.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1988 , vol. 37, # 1 p. 91 - 95
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1988 , # 1 p. 101 - 105
反应条件
ammonium thiocyanate
T=60°C; 0.666667 h; Neat (no solvent);
参考文献
Akhlaghinia, Batool; Rahimizadeh, Mohammad; Eshghi, Hosein; Zhaleh, Sara; Rezazadeh, Soodabeh
Journal of Sulfur Chemistry, 2012 , vol. 33, # 3 p. 351 - 361
反应条件
DBN in tetrahydrofuran; acetonitrile
1) addition 0 deg C, 2) 65 deg C, 1 h;
参考文献
Detty, Michael R.
Journal of Organic Chemistry, 1980 , vol. 45, # 5 p. 924 - 926
反应条件
in acetonitrile
T=0°C; Yield given;
参考文献
Detty, Michael R.
Journal of Organic Chemistry, 1980 , vol. 45, # 5 p. 924 - 926
反应条件
in acetonitrile
T=0°C; 0.0833333 h; Yield given. Yields of byproduct given;
参考文献
Detty, Michael R.; Seidler, Mark D.
Journal of Organic Chemistry, 1981 , vol. 46, # 7 p. 1283 - 1292
反应条件
(i) CuCN, Et2O, (ii) /BRN= 102878/; Multistep reaction;
参考文献
Acker,R.-D.
Tetrahedron Letters, 1977 , # 39 p. 3407 - 3410
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; (1S,3R,4R)-3-(N-pyrrolidinyl)methyl-2-azabicyclo[2.2.1]heptane; lithium diisopropyl amide in tetrahydrofuran; hexane
T=0°C; Ring cleavage; 4 h;
参考文献
Soedergren, Mikael J.; Bertilsson, Sophie K.; Andersson, Pher G.
Journal of the American Chemical Society, 2000 , vol. 122, # 28 p. 6610 - 6618
反应条件
1: With n-butyllithium; diisopropylamine; 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran; hexane
T=0°C; 4 h;
2: With ammonium chloride in tetrahydrofuran
Further stages.;
参考文献
Gayet, Arnaud; Bertilsson, Sophie; Andersson, Pher G.
Organic Letters, 2002 , vol. 4, # 22 p. 3777 - 3779
反应条件
boron trifluoride diethyl etherate in chloroform
参考文献
Sugihara, Yoshiaki; Iimura, Shinya; Nakayama, Juzo
Chemical Communications, 2002 , # 2 p. 134 - 135
反应条件
toluene-4-sulfonic acid in dichloromethane
T=20°C; 2 h; regioselective reaction;
参考文献
Chapman, Helen A.; Herbal, Karim; Motherwell, William B.
Synlett, 2010 , # 4 art. no. D37609ST, p. 595 - 598
