3-甲基-3-哌啶甲酸乙酯合成路线 （共 8 条）
反应条件
1: With hydrogenchloride; hydrogen; platinum(IV) oxide in ethanol; water T=40°C; P=760.051 Torr; 2 h; 2: With triethylamine in ethanol T=0 - 20°C; 16 h;
参考文献
WO2009/13390 A1, ;
Page/Page column 71 ;
WO 2009/013390 A1
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; 2.5 h;
参考文献
EP1553074 A1, ;
Page/Page column 41 ;
反应条件
1: piperidine-3-carboxylic acid ethyl ester With sodium hexamethyldisilazane in toluene T=-35 - -20°C; 0.5 h; 2: methyl iodide in toluene T=-25 - 20°C;
参考文献
WO2009/16084 A1, ;
Page/Page column 53-54 ;
WO 2009/016084 A1
反应条件
trifluoroacetic acid
参考文献
Coppola, Gary M; Damon, Robert E; Eskesen, J Bruce; France, Dennis S; Paterniti Jr., James R
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 17 p. 2439 - 2442
反应条件
1.1: LDA / tetrahydrofuran / -78 °C 1.2: 90 percent / tetrahydrofuran 2.1: 85 percent / TFA View Scheme
参考文献
Bioorganic and medicinal chemistry letters, , vol. 12, # 17 p. 2439 - 2442
反应条件
1.1: LDA / tetrahydrofuran / -78 °C 1.2: 90 percent / tetrahydrofuran 2.1: 85 percent / TFA View Scheme
参考文献
Bioorganic and medicinal chemistry letters, , vol. 12, # 17 p. 2439 - 2442
反应条件
1.1: N,N'-dimethyl-N,N'-propyleneurea; lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - -60 °C 1.2: 2.5 h / -60 - -20 °C 2.1: hydrogen; 5 palladium on charcoal / methanol; ethyl acetate / 1.5 h View Scheme
参考文献
WO2013/12829 A1, ;
WO 2013/012829 A1
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=18 - 25°C; 15 h; 2: With sodium hydroxide; ammonia; water; Sodium potassium tartrate in tetrahydrofuran T=-5°C; 0.5 h;
参考文献
EP1015431 B1, ;
Page/Page column 28 ;
EP 1015431 B1
