2-苯基-1,3-二氧六环-5-醇合成路线 （共 45 条）
反应条件
pyridine in dichloromethane; chloroform; water
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4576933 A1, 1986 ;
反应条件
1: 97 percent / NaH / tetrahydrofuran / 4 h / 55 °C
2: 96 percent / borane-THF complex / 60 h / 20 - 45 °C
3: 1.) NaH / 1.) DMF, THF, 0 deg C, 2.) DMF, THF, 20 deg C, 24 h
View Scheme
参考文献
Pinchuk, A. N.; Mitsner, B. I.; Shvets, V. I.
Pharmaceutical Chemistry Journal, 1992 , vol. 26, # 2 p. 174 - 176
Khimiko-Farmatsevticheskii Zhurnal, 1992 , vol. 26, # 2 p. 62 - 64
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in toluene
T=20°C; 12 h;
参考文献
Suhara, Yoshitomo; Oka, Saori; Kittaka, Atsushi; Takayama, Hiroaki; Waku, Keizo; Sugiura, Takayuki
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 854 - 867
反应条件
1: 75 percent / N,N'-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / toluene / 12 h / 20 °C
2: 72 percent / O3 / methanol; CH2Cl2 / 1 h / -78 °C
View Scheme
参考文献
Suhara, Yoshitomo; Oka, Saori; Kittaka, Atsushi; Takayama, Hiroaki; Waku, Keizo; Sugiura, Takayuki
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 854 - 867
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in toluene
T=20°C;
参考文献
Suhara, Yoshitomo; Oka, Saori; Kittaka, Atsushi; Takayama, Hiroaki; Waku, Keizo; Sugiura, Takayuki
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 854 - 867
反应条件
1: 70 percent / N,N'-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / toluene / 20 °C
2: 74 percent / O3 / methanol; CH2Cl2 / cooling
View Scheme
参考文献
Suhara, Yoshitomo; Oka, Saori; Kittaka, Atsushi; Takayama, Hiroaki; Waku, Keizo; Sugiura, Takayuki
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 854 - 867
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane
T=0 - 20°C; 4 h;
参考文献
Kim, Young-Ah; Park, Myoung-Soon; Kim, Young Hwan; Han, So-Yeop
Tetrahedron, 2003 , vol. 59, # 16 p. 2921 - 2928
参考文献
Stimmel; King
Journal of the American Chemical Society, 1934 , vol. 56, p. 1725
反应条件
pyridine; thionyl chloride
参考文献
Tsatsas
Annales Pharmaceutiques Francaises, 1950 , vol. 8, p. 273,285
反应条件
1: 94 percent / potassium tert-butoxide / dimethylsulfoxide / 0.5 h / 20 °C
2: LiAlH4; AlCl3 / CH2Cl2; diethyl ether / 1 h / 20 °C
View Scheme
参考文献
Takano, Seiichi; Akiyama, Masashi; Sato, Seiji; Ogasawara, Kunio
Chemistry Letters, 1983 , p. 1593 - 1596
